ESR1_ARATH
ID ESR1_ARATH Reviewed; 328 AA.
AC Q9SAD4; Q8W258;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Ethylene-responsive transcription factor ESR1;
DE AltName: Full=Protein DORNROSCHEN;
DE AltName: Full=Protein ENHANCER OF SHOOT REGENERATION 1;
GN Name=ESR1; Synonyms=DRN, ERF089; OrderedLocusNames=At1g12980;
GN ORFNames=F3F19.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY
RP CYTOKININS.
RC STRAIN=cv. Wassilewskija;
RX PubMed=11752375; DOI=10.2307/3871522;
RA Banno H., Ikeda Y., Niu Q.-W., Chua N.-H.;
RT "Overexpression of Arabidopsis ESR1 induces initiation of shoot
RT regeneration.";
RL Plant Cell 13:2609-2618(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=12615942; DOI=10.1105/tpc.009480;
RA Kirch T., Simon R., Gruenewald M., Werr W.;
RT "The DORNROSCHEN/ENHANCER OF SHOOT REGENERATION1 gene of Arabidopsis acts
RT in the control of meristem cell fate and lateral organ development.";
RL Plant Cell 15:694-705(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH ATHB-8; CNA; PHB; PHV AND
RP REV, AND DEVELOPMENTAL STAGE.
RX PubMed=17376809; DOI=10.1242/dev.001016;
RA Chandler J.W., Cole M., Flier A., Grewe B., Werr W.;
RT "The AP2 transcription factors DORNROSCHEN and DORNROSCHEN-LIKE redundantly
RT control Arabidopsis embryo patterning via interaction with PHAVOLUTA.";
RL Development 134:1653-1662(2007).
CC -!- FUNCTION: Regulates gene expression patterns in meristems and thus
CC modulates organ development. Required for correct embryo patterning and
CC cotyledon organogenesis. Modulates auxin signaling pathway in early
CC embryos. Involved in the cytokinin signaling pathway that promotes
CC shoot regeneration. Acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:11752375, ECO:0000269|PubMed:12615942,
CC ECO:0000269|PubMed:17376809}.
CC -!- SUBUNIT: Interacts with class 3 HD-ZIP proteins such as ATHB-8, CNA,
CC PHB, PHV, and REV. {ECO:0000269|PubMed:17376809}.
CC -!- INTERACTION:
CC Q9SAD4; O04292: ATHB-9; NbExp=5; IntAct=EBI-1536756, EBI-1536772;
CC Q9SAD4; Q9LEZ3: BIM1; NbExp=4; IntAct=EBI-1536756, EBI-617095;
CC Q9SAD4; Q9FJ49: PYL12; NbExp=3; IntAct=EBI-1536756, EBI-2363244;
CC Q9SAD4; Q8S8E3: PYL6; NbExp=3; IntAct=EBI-1536756, EBI-2363192;
CC Q9SAD4; Q84MC7: PYL9; NbExp=3; IntAct=EBI-1536756, EBI-2349513;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in shoot apical and floral meristems, and
CC in organ primordia. Transient expression during shoot regeneration.
CC {ECO:0000269|PubMed:11752375, ECO:0000269|PubMed:12615942,
CC ECO:0000269|PubMed:17376809}.
CC -!- DEVELOPMENTAL STAGE: First observed in the embryo at four-cell stage.
CC At the globular stage, localized in cotyledons primordia. Later
CC confined to embryonic cotyledons tips. Expressed from embryogenesis
CC onward in the central zone of the shoot apical and floral meristems, in
CC organ anlagen, and (transiently) in the distal domains of organ
CC primordia. {ECO:0000269|PubMed:12615942, ECO:0000269|PubMed:17376809}.
CC -!- INDUCTION: By cytokinins. {ECO:0000269|PubMed:11752375}.
CC -!- MISCELLANEOUS: 'Dornroeschen' means 'Sleeping beauty' in German.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; AF353577; AAL56226.1; -; mRNA.
DR EMBL; AC007357; AAD31052.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28956.1; -; Genomic_DNA.
DR PIR; G86263; G86263.
DR RefSeq; NP_172758.1; NM_101169.3.
DR AlphaFoldDB; Q9SAD4; -.
DR SMR; Q9SAD4; -.
DR BioGRID; 23096; 7.
DR IntAct; Q9SAD4; 5.
DR STRING; 3702.AT1G12980.1; -.
DR PaxDb; Q9SAD4; -.
DR PRIDE; Q9SAD4; -.
DR EnsemblPlants; AT1G12980.1; AT1G12980.1; AT1G12980.
DR GeneID; 837856; -.
DR Gramene; AT1G12980.1; AT1G12980.1; AT1G12980.
DR KEGG; ath:AT1G12980; -.
DR Araport; AT1G12980; -.
DR TAIR; locus:2031890; AT1G12980.
DR eggNOG; ENOG502RE27; Eukaryota.
DR HOGENOM; CLU_848224_0_0_1; -.
DR InParanoid; Q9SAD4; -.
DR OMA; EMLMYGT; -.
DR OrthoDB; 1585896at2759; -.
DR PRO; PR:Q9SAD4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SAD4; baseline.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009880; P:embryonic pattern specification; IMP:TAIR.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:1905392; P:plant organ morphogenesis; IMP:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR GO; GO:0090708; P:specification of plant organ axis polarity; IMP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; Auxin signaling pathway; Cytokinin signaling pathway;
KW DNA-binding; Ethylene signaling pathway; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..328
FT /note="Ethylene-responsive transcription factor ESR1"
FT /id="PRO_0000297927"
FT DNA_BIND 56..113
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 259
FT /note="N -> A (in Ref. 1; AAL56226)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 328 AA; 36319 MW; 66320534B5FCAE6B CRC64;
MEKALRNFTE STHSPDPNPL TKFFTEPTAS PVSRNRKLSS KDTTVTIAGA GSSTTRYRGV
RRRPWGRYAA EIRDPMSKER RWLGTFDTAE QAACAYDSAA RAFRGAKART NFTYPTAVIM
PEPRFSFSNK KSSPSARCPL PSLPLDSSTQ NFYGAPAAQR IYNTQSIFLR DASCSSRKTT
PYNNSFNGSS SSYSASKTAC VSYSENENNE SFFPEESSDT GLLQEVVQEF LKKNRGVPPS
PPTPPPVTSH HDNSGYFSNL TIYSENMVQE TKETLSSKLD RYGNFQANDD GVRAVADGGL
SLGSNEWGYQ EMLMYGTQLG CTCRRSWG
