ESR1_ICTPU
ID ESR1_ICTPU Reviewed; 617 AA.
AC Q9YHZ7;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Estrogen receptor;
DE Short=ER;
DE AltName: Full=ER-alpha;
DE AltName: Full=Estradiol receptor;
DE AltName: Full=Nuclear receptor subfamily 3 group A member 1;
GN Name=esr1; Synonyms=esr, nr3a1;
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RC TISSUE=Liver, and Ovary;
RX PubMed=11121296; DOI=10.1006/gcen.2000.7566;
RA Patino R., Xia Z., Gale W.L., Wu C., Maule A.G., Chang X.;
RT "Novel transcripts of the estrogen receptor alpha gene in channel
RT catfish.";
RL Gen. Comp. Endocrinol. 120:314-325(2000).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=10753576; DOI=10.1006/gcen.1999.7447;
RA Xia Z., Gale W.L., Chang X., Langenau D., Patino R., Maule A.G.,
RA Densmore L.D.;
RT "Phylogenetic sequence analysis, recombinant expression, and tissue
RT distribution of a channel catfish estrogen receptor beta.";
RL Gen. Comp. Endocrinol. 118:139-149(2000).
CC -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC regulation of eukaryotic gene expression and affect cellular
CC proliferation and differentiation in target tissues.
CC -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-beta
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9YHZ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9YHZ7-2; Sequence=VSP_003681;
CC Name=3;
CC IsoId=Q9YHZ7-3; Sequence=VSP_003682;
CC -!- TISSUE SPECIFICITY: Ovary and testis. {ECO:0000269|PubMed:10753576}.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000305}.
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DR EMBL; AF253505; AAG24543.1; -; mRNA.
DR EMBL; AF061275; AAC69548.1; -; mRNA.
DR EMBL; AF253506; AAG24544.1; -; mRNA.
DR RefSeq; NP_001187003.1; NM_001200074.1. [Q9YHZ7-1]
DR RefSeq; XP_017310819.1; XM_017455330.1. [Q9YHZ7-1]
DR AlphaFoldDB; Q9YHZ7; -.
DR SMR; Q9YHZ7; -.
DR STRING; 7998.ENSIPUP00000028831; -.
DR GeneID; 100304474; -.
DR KEGG; ipu:100304474; -.
DR CTD; 2099; -.
DR OrthoDB; 487299at2759; -.
DR Proteomes; UP000221080; Chromosome 25.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042562; F:hormone binding; IDA:AgBase.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IDA:AgBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IMP:AgBase.
DR GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IMP:AgBase.
DR GO; GO:0050776; P:regulation of immune response; IMP:AgBase.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR001292; Estr_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF02159; Oest_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500101; ER-a; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Lipid-binding; Metal-binding; Nucleus;
KW Receptor; Steroid-binding; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..617
FT /note="Estrogen receptor"
FT /id="PRO_0000053629"
FT DOMAIN 316..552
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 187..252
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 187..207
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 223..247
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..186
FT /note="Modulating"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..315
FT /note="Hinge"
FT REGION 269..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..425
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_003682"
FT VAR_SEQ 1..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_003681"
SQ SEQUENCE 617 AA; 67671 MW; 7B208558E5EAD403 CRC64;
MSEEQARAEA PAGARQRRRS ELEGYSVSLA SLKLSPMYPE EEQRTTGGIS STAHYLDGTF
NYTTNPDATN SSVDYYSVAP EPQEENLQPL PNGSSSPPVF VPSSPQLSPF LGHPPAGQHT
AQQVPYYLEP SGTSIYRSSV LASAGSRVEL CSAPGRQDVY TAVGASGPSG ASGPSGAIGL
VKEIRYCSVC SDYASGYHYG VWSCEGCKAF FKRSIQGHND YVCPATNQCT IDRNRRKSCQ
ACRLRKCYEV GMMKGGFRKE RGGRIIKHNR RPSGLKERER GYSKAQSGSD VREALPQDGQ
SSSGIGGGVA DVVCMSPEQV LLLLLRAEPP TLCSRQKHSR PYSELTIMSL LTNMADRELV
HMIAWAKKVP GFQDLSLHDQ VQLLESSWLE ILMIGLIWRS IYTPGKLIFA QDLILDKSEG
ECVEGMAEIF DMLLATVARF RTLKLKSEEF VCLKAIILLN SGAFSFCSSP VEPLRDGFMV
QCMMDNITDA LIYYISQSGI SVQLQSRRQA QLLLLLSHIR HMSYKGMEHL YSMKCKNKVP
LYDLLLEMLD AHRLRPLGKV PRIWADRVSS SPTTTATTPT TNTTTTTTTT THHPSNGSTC
PADLPSNPPG PGQSPSP
