ESR1_OREAU
ID ESR1_OREAU Reviewed; 583 AA.
AC P50240;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Estrogen receptor;
DE Short=ER;
DE AltName: Full=ER-alpha;
DE AltName: Full=Estradiol receptor;
DE AltName: Full=Nuclear receptor subfamily 3 group A member 1;
GN Name=esr1; Synonyms=esr, nr3a1;
OS Oreochromis aureus (Israeli tilapia) (Chromis aureus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=47969;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8961252; DOI=10.1016/s0303-7207(96)03911-1;
RA Tan N.S., Lam T.J., Ding J.L.;
RT "Transcription regulatory signals in the 5' and 3' regions of Oreochromis
RT aureus ER gene.";
RL Mol. Cell. Endocrinol. 123:149-161(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-583.
RC TISSUE=Blood;
RX PubMed=8777315; DOI=10.3109/10425179509020867;
RA Tan N.S., Lam T.J., Ding J.L.;
RT "Molecular cloning and sequencing of the hormone-binding domain of
RT Oreochromis aureus estrogen receptor gene.";
RL DNA Seq. 5:359-370(1995).
CC -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC regulation of eukaryotic gene expression and affect cellular
CC proliferation and differentiation in target tissues.
CC -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-beta
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000305}.
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DR EMBL; X93557; CAA63774.1; -; Genomic_DNA.
DR EMBL; X93558; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; X93559; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; X93560; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; Z46665; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; Z46666; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; Z46667; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; Z46668; CAA63774.1; JOINED; Genomic_DNA.
DR EMBL; Z46669; CAA63774.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; P50240; -.
DR SMR; P50240; -.
DR Proteomes; UP000472276; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR001292; Estr_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF02159; Oest_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500101; ER-a; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Steroid-binding; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..583
FT /note="Estrogen receptor"
FT /id="PRO_0000053632"
FT DOMAIN 266..501
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 139..204
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 139..159
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 175..199
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..138
FT /note="Modulating"
FT /evidence="ECO:0000250"
FT REGION 205..265
FT /note="Hinge"
FT REGION 220..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 64030 MW; 20CFE85CAFB36A0E CRC64;
MYPEESRGSG GVATVDFLEG LMTMTAPTPA PTPLYSHSTT GCYSAPLDAH GPLSDGSLQS
LGSGPTSPLV FVPSSPRLSP FMHPPSHHYL ETTSTPVYRS SHQPVPREDQ CGTRDEAYSV
GELGAGAGGF EITKNTRFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYMCPATNQ
CTIDKNRRKS CQACRLRKCY EVGMMKGGMR KDRGRVLRRE KHGPAQRQTS QNLPTHKASP
QDGRKRAMSS SSTSGPGGRS SLNNMPPDQV LLLLQGAEPP ILCSRQKMSR PYTEVTIMTL
LTSMADKELV HMITWAKKLP GFLQLSLHDQ VLLLESSWLE VLMIGLIWRS IQCPGKLIFE
EDLILDRNEG TCVEGMAEIF DMLLATVRFR VLKLKPEEFV CLKAIILLNS GAFSFCTGTM
EPLHDSVAVQ HMLDTITDAL IFHISHFGCS AQQQSRRQAQ LLLLLSHIRH MSNKGMEHLY
SMKCKNKVPL YDLLLEMLDA HRIHRPVKPS QSWSQGDRDS PTASSTSSRG GGGGDDEGAS
SAGSSSGPQG SHESPRRENL SRAPKGPGVL QYRGSHSDCT RIP
