ESR1_ORYLA
ID ESR1_ORYLA Reviewed; 620 AA.
AC P50241;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Estrogen receptor;
DE Short=ER;
DE AltName: Full=ER-alpha;
DE AltName: Full=Estradiol receptor;
DE AltName: Full=Nuclear receptor subfamily 3 group A member 1;
GN Name=esr1; Synonyms=esr, mer, nr3a1;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=D-RR; TISSUE=Liver;
RX PubMed=18517300; DOI=10.2108/zsj.17.643;
RA Kawahara T., Okada H., Yamashita I.;
RT "Cloning and expression of genomic and complementary DNAs encoding an
RT estrogen receptor in the medaka fish, Oryzias latipes.";
RL Zool. Sci. 17:643-649(2000).
CC -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC regulation of eukaryotic gene expression and affect cellular
CC proliferation and differentiation in target tissues.
CC -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-beta
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Widely expressed in brain, ovary, testis, and
CC female liver. {ECO:0000269|PubMed:18517300}.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000305}.
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DR EMBL; D28954; BAA25900.1; -; mRNA.
DR EMBL; AB033491; BAA86925.1; -; Genomic_DNA.
DR PIR; T10423; T10423.
DR AlphaFoldDB; P50241; -.
DR SMR; P50241; -.
DR STRING; 8090.ENSORLP00000018192; -.
DR Ensembl; ENSORLT00000018193; ENSORLP00000018192; ENSORLG00000014514.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000158133; -.
DR InParanoid; P50241; -.
DR OrthoDB; 487299at2759; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Proteomes; UP000265180; Unplaced.
DR Proteomes; UP000265200; Unplaced.
DR Bgee; ENSORLG00000014514; Expressed in testis and 4 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030518; P:intracellular steroid hormone receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR001292; Estr_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF02159; Oest_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500101; ER-a; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Steroid-binding; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..620
FT /note="Estrogen receptor"
FT /id="PRO_0000053634"
FT DOMAIN 315..551
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 186..251
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 186..206
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 222..246
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..185
FT /note="Modulating"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..314
FT /note="Hinge"
FT REGION 286..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 67729 MW; DDCBD18C2B2BA522 CRC64;
MSKRQSSVQI RQLFGPALRS RISPASSELE TLSPPRLSPR DPLGDMYPEE SRGSGGVAAV
DFLEGTYDYA APNPATTPLY SQSSTGYYSA PLETNGPPSE GSLQSLGSGP TSPLVFVPSS
PRLSPFMHPP SHHYLETTST PVYRSSHQGA SREDQCGSRE DTCSLGELGA GAGAGGFEMA
KDTRFCAVCS DYASGYHYGV WSCEGCKAFF KRSIQGHNDY MCPATNQCTI DRNRRKSCQA
CRLRKCYEVG MMKGGVRKDR IRILRRDKRR TGVGDGDKVV KGQEHKTVHY DGRKRSSTGG
GGGGGGGRLS VTSIPPEQVL LLLQGAEPPI LCSRQKLSRP YTEVTMMTLL TSMADKELVH
MIAWAKKLPG FLQLSLHDQV LLLESSWLEV LMIGLIWRSI HCPGKLIFAQ DLILDRNEGD
CVEGMTEIFD MLLATASRFR VLKLKPEEFV CLKAIILLNS GAFSFCTGTM EPLHNSAAVQ
SMLDTITDAL IHYISQSGYL AQEQARRQAQ LLLLLSHIRH MSNKGMEHLY SMKCKNKVPL
YDLLLEMLDA HRLHHPVRAP QSLSQVDRDP PSTSSGGGGI APGSISASRG RIESPSRGPF
APSVLQYGGS RPDCTPALQD
