ID   ESR1_PAGMA              Reviewed;         581 AA.
AC   O42132;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Estrogen receptor;
DE            Short=ER;
DE   AltName: Full=ER-alpha;
DE   AltName: Full=Estradiol receptor;
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 1;
GN   Name=esr1; Synonyms=esr, nr3a1;
OS   Pagrus major (Red sea bream) (Chrysophrys major).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Pagrus.
OX   NCBI_TaxID=143350;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Touhata K., Kinoshita M., Toyohara H., Sakaguchi M.;
RT   "Sequence and expression of a cDNA encoding the red seabream estrogen
RT   receptor.";
RL   Fish. Sci. 64:131-135(1998).
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC       regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-beta
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB007453; BAA22517.1; -; mRNA.
DR   AlphaFoldDB; O42132; -.
DR   SMR; O42132; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR001292; Estr_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF02159; Oest_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500101; ER-a; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Steroid-binding; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..581
FT                   /note="Estrogen receptor"
FT                   /id="PRO_0000053635"
FT   DOMAIN          273..509
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        145..210
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         145..165
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         181..205
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..144
FT                   /note="Modulating"
FT                   /evidence="ECO:0000250"
FT   REGION          45..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..272
FT                   /note="Hinge"
FT   REGION          216..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..581
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..571
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  63461 MW;  D499BB6E7B4EB964 CRC64;
     MYPEDSRGSG GVATVDFLEG TYDYAAPTPA PTPLYSHSTP GYYSAPLDAH GPPSDGSLQS
     LGSGPNSPLV FVPSSPRLSP FMHPPTHHYL ETTSTPVYRS SVPSSQQSVS REDQCGTSDD
     SYSVGESGAG ALAAGFEIAK EMRFCAVCSD YASGYHYGVW SCEGCKAFFK RSIQGHNDYM
     CPATNQCTID RNRRKSCQAC RLRKCYEVGM MKGGMRKDRG RVLRRDKQRT GTSDRDKASK
     GLEHRTAPPQ DRRKHISSSA GGGGGKSSMI SMPPDQVLLL LQGAEPPMLC SRQKLNRPYT
     EVTMMTLLTS MADKELVHMI AWAKKLPGFL QLSLHDQVQL LESSWLEVLM IGLIWRSIHC
     PGKLIFAQDL ILDRSEGDCV EGMAEIFDML LATASRFRML KLKPEEFVCL KAIILLNSGA
     FSFCTGTMEP LHDGAAVQNM LDTITDALIH HINQSGCSAQ QQSRRQAQLL LLLSHIRHMS
     NKGMEHLYSM KCKNKVPLYD LLLEMLDAHR IHRADRPAET WSQADREPPF TSRNSSGGGG
     GGGGGSSSAG STSGPRVSHE SPTSPGVLQY GGSRSECTHI L