ESR1_SPAAU
ID ESR1_SPAAU Reviewed; 581 AA.
AC Q9PVZ9; O42174; Q9PWP6;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Estrogen receptor;
DE Short=ER;
DE AltName: Full=ER-alpha;
DE AltName: Full=Estradiol receptor;
DE AltName: Full=Nuclear receptor subfamily 3 group A member 1;
GN Name=esr1; Synonyms=esr, nr3a1;
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=10376207; DOI=10.3109/10425179909008421;
RA Munoz-Cueto J.A., Burzawa-Gerard E., Kah O., Valotaire Y., Pakdel F.;
RT "Cloning and sequencing of the gilthead sea bream estrogen receptor cDNA.";
RL DNA Seq. 10:75-84(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pinto P., Canario A.V.M.;
RT "The estrogen receptor in sea bream (Sparus auratus) reproduction:
RT diversity, expression, mechanisms and physiological actions.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 52-581.
RC TISSUE=Liver;
RX PubMed=10927619; DOI=10.1677/joe.0.1660293;
RA Socorro S., Power D.M., Olsson P.-E., Canario A.V.M.;
RT "Two estrogen receptors expressed in the teleost fish, Sparus aurata: cDNA
RT cloning, characterization and tissue distribution.";
RL J. Endocrinol. 166:293-306(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 210-485.
RC TISSUE=Liver;
RA Socorro S., Power D.M., Canario A.V.M.;
RT "cDNA cloning and tissue expression of the gilthead sea-bream, Sparus
RT aurata, estrogen receptor.";
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC regulation of eukaryotic gene expression and affect cellular
CC proliferation and differentiation in target tissues.
CC -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-beta
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000305}.
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DR EMBL; AJ006039; CAB51479.1; -; mRNA.
DR EMBL; AF136979; AAD31032.2; -; mRNA.
DR EMBL; AF013104; AAB82428.1; -; mRNA.
DR AlphaFoldDB; Q9PVZ9; -.
DR SMR; Q9PVZ9; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR001292; Estr_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF02159; Oest_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500101; ER-a; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Steroid-binding; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..581
FT /note="Estrogen receptor"
FT /id="PRO_0000053638"
FT DOMAIN 273..509
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 142..217
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 145..165
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 181..200
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..144
FT /note="Modulating"
FT /evidence="ECO:0000250"
FT REGION 45..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..272
FT /note="Hinge"
FT REGION 216..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 83..86
FT /note="HPPT -> QPAN (in Ref. 1; CAB51479)"
FT /evidence="ECO:0000305"
FT CONFLICT 99..100
FT /note="Missing (in Ref. 1; CAB51479)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="K -> N (in Ref. 4; AAB82428)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 581 AA; 63627 MW; 19203C85F7CF3FDF CRC64;
MYPEDSRVSG GVATVDFLEG TYDYAAPTPA PTPLYSHSTP GYYSAPLDAH GPPSDGSLQS
LGSGPNSPLV FVPSSPHLSP FMHPPTHHYL ETTSTPIYRS SVPSSQHSVS REDQCGTSDD
SYSVGESGAG AGAAGFEMAK EMRFCAVCSD YASGYHYGVW SCEGCKAFFK RSIQGHNDYM
CPATNQCTID RNRRKSCQAC RLRKCYEVGM MKGGVRKDRG RVLRRDKRRT GTSDRDKASK
GLEHRTAPPQ DRRKHISSSA GGGGGKSSVI SMPPDQVLLL LRGAEPPMLC SRQKVNRPYT
EVTVMTLLTS MADKELVHMI AWAKKLPGFL QLSLHDQVQL LESSWLEVLM IGLIWRSIHC
PGKLIFAQDL ILDRSEGDCV EGMAEIFDML LATASRFRML KLKPEEFVCL KAIILLNSGA
FSFCTGTMEP LHDSAAVQNM LDTITDALIH HINQSGCSAQ QQSRRQAQLL LLLSHIRHMS
NKGMEHLYSM KCKNKVPLYD LLLEMLDAHR VHRPDRPAET WSQADREPLF TSRNSSSSSG
GGGGGSSSAG STSGPQVNLE SPTGPGVLQL RVHPHPMKPT E
