ID   ESR21_CARAU             Reviewed;         568 AA.
AC   Q9W669;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Estrogen receptor beta-1;
DE            Short=ER-beta-1;
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 2-A;
GN   Name=esr2a; Synonyms=nr3a2a;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=10068500; DOI=10.1006/gcen.1998.7217;
RA   Tchoudakova A.V., Pathak S., Callard G.V.;
RT   "Molecular cloning of an estrogen receptor beta subtype from the goldfish,
RT   Carassius auratus.";
RL   Gen. Comp. Endocrinol. 113:388-400(1999).
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-alpha,
CC       and activates expression of reporter genes containing estrogen response
CC       elements (ERE) in an estrogen-dependent manner.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-alpha
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF061269; AAD26921.1; -; mRNA.
DR   AlphaFoldDB; Q9W669; -.
DR   SMR; Q9W669; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR   GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR021064; ER-beta-like_N.
DR   InterPro; IPR028355; ER-beta/gamma.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF12497; ERbeta_N; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500102; ER-b; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Steroid-binding; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..568
FT                   /note="Estrogen receptor beta-1"
FT                   /id="PRO_0000053652"
FT   DOMAIN          292..528
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        170..235
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         170..190
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         206..230
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          12..169
FT                   /note="Modulating"
SQ   SEQUENCE   568 AA;  63540 MW;  2D678D0775DB76F9 CRC64;
     MTALNSYAFA MSEYAEGDSS LLQLQEVDSS RMGGHVLSPT FNSSSPSLPV ESHPICIPSP
     YTDLGHDFTT LPFYSPSLLG YGTSPLSDCP SVRQSLSPTL FWPPHSHVSS LALHQQQTRL
     QPNHPTGGTW AELTPHDHGE EENCKPLSKR VAVAEETSTS LRGKADMHYC AVCSDYASGY
     HYGVWSCEGC KAFFKRSIQG HNDYICPATN QCTIDKNRRK SCQACRLRKC YEVGMMKCGL
     RRDRSSYQQR GAQQNRLTRF SGRMRTSGPR SQEIKTVQRP LSGNKVVTMA LSPEELIARI
     MDAEPPEIYL MKDVKKPFTE ANVMMSLTNL ADKELVHMIS WAKKIPGFVE IGLFDQVHLL
     ECCWLEVLML GLMWRSVNHP GKLVFSPDLS LSRDEGSCVQ GFAEIFDMLL AATSRFRELK
     LQREEYACLK AMILLNSNMC LSSAEGGEEL QSRSKLLCLL DSVTDALVWA ISKTGLSFQQ
     RSTRLAHLLM LLSHIRHVSN KGMDHLHSMK MKKMVPLYDL LLEMLDAHIM HGSRLSHSGP
     QADPVPKESN CVQETFTCTS QHGGTLRP