ESR2_ARATH
ID ESR2_ARATH Reviewed; 306 AA.
AC Q9FYK5;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Ethylene-responsive transcription factor ESR2;
DE AltName: Full=Protein DORNROESCHEN-LIKE;
DE Short=Protein DRN-LIKE;
DE AltName: Full=Protein ENHANCER OF SHOOT REGENERATION 2;
DE AltName: Full=Protein SUPPRESSOR OF PHYTOCHROMEB 2;
GN Name=ESR2; Synonyms=DRNL, ERF090, SOB2; OrderedLocusNames=At1g24590;
GN ORFNames=F21J9.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pan Y., Gong W., Liu D., Fu Q., Mei W.-Q., Song W.-Q., Ma L.-G., Luo J.-C.,
RA Deng X.-W., Zhu Y.-X.;
RT "Molecular cloning, expression, phylogenetic and functional
RT characterization of the Arabidopsis AP2/EREBP transcription factor
RT family.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RX PubMed=16339853; DOI=10.1105/tpc.105.036707;
RA Ward J.M., Smith A.M., Shah P.K., Galanti S.E., Yi H., Demianski A.J.,
RA van der Graaff E., Keller B., Neff M.M.;
RT "A new role for the Arabidopsis AP2 transcription factor, LEAFY PETIOLE, in
RT gibberellin-induced germination is revealed by the misexpression of a
RT homologous gene, SOB2/DRN-LIKE.";
RL Plant Cell 18:29-39(2006).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17056621; DOI=10.1093/pcp/pcl023;
RA Ikeda Y., Banno H., Niu Q.-W., Howell S.H., Chua N.-H.;
RT "The ENHANCER OF SHOOT REGENERATION 2 gene in Arabidopsis regulates CUP-
RT SHAPED COTYLEDON 1 at the transcriptional level and controls cotyledon
RT development.";
RL Plant Cell Physiol. 47:1443-1456(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH ATHB-8; CNA; PHB; PHV AND
RP REV, AND DEVELOPMENTAL STAGE.
RX PubMed=17376809; DOI=10.1242/dev.001016;
RA Chandler J.W., Cole M., Flier A., Grewe B., Werr W.;
RT "The AP2 transcription factors DORNROSCHEN and DORNROSCHEN-LIKE redundantly
RT control Arabidopsis embryo patterning via interaction with PHAVOLUTA.";
RL Development 134:1653-1662(2007).
CC -!- FUNCTION: Required for correct embryo patterning and cotyledon
CC organogenesis. May regulate positively the gibberellin signaling
CC pathway leading to germination, hypocotyl elongation, and leaf
CC expansion. Involved in the cytokinin signaling pathway that promotes
CC shoot regeneration, probably through transcriptional activation of
CC target genes such as CUC1. Acts as a transcriptional activator. Binds
CC to the GCC-box pathogenesis-related promoter element. May be involved
CC in the regulation of gene expression by stress factors and by
CC components of stress signal transduction pathways (By similarity).
CC {ECO:0000250, ECO:0000269|PubMed:16339853, ECO:0000269|PubMed:17056621,
CC ECO:0000269|PubMed:17376809}.
CC -!- SUBUNIT: Interacts with class 3 HD-ZIP proteins such as ATHB-8, CNA,
CC PHB, PHV, and REV. {ECO:0000269|PubMed:17376809}.
CC -!- INTERACTION:
CC Q9FYK5; Q9SX22: At1g68590; NbExp=3; IntAct=EBI-1536925, EBI-4424705;
CC Q9FYK5; A0A178VUV0: At2g24860; NbExp=3; IntAct=EBI-1536925, EBI-25521598;
CC Q9FYK5; Q9LYL6: At3g56270; NbExp=3; IntAct=EBI-1536925, EBI-1238139;
CC Q9FYK5; Q8GYP4: At4g18630/F28A21_40; NbExp=3; IntAct=EBI-1536925, EBI-1239007;
CC Q9FYK5; Q945P2: At5g49210; NbExp=5; IntAct=EBI-1536925, EBI-4436601;
CC Q9FYK5; O04292: ATHB-9; NbExp=2; IntAct=EBI-1536925, EBI-1536772;
CC Q9FYK5; A0A178VYP6: AXX17_At2g35160; NbExp=3; IntAct=EBI-1536925, EBI-25521512;
CC Q9FYK5; A0A178VN99: AXX17_At2g40150; NbExp=3; IntAct=EBI-1536925, EBI-25521581;
CC Q9FYK5; Q9LEZ3: BIM1; NbExp=2; IntAct=EBI-1536925, EBI-617095;
CC Q9FYK5; Q94ID6: ERF12; NbExp=4; IntAct=EBI-1536925, EBI-4446727;
CC Q9FYK5; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-1536925, EBI-2000137;
CC Q9FYK5; Q39103: GA3OX1; NbExp=5; IntAct=EBI-1536925, EBI-4426378;
CC Q9FYK5; Q8LF89: GRXC8; NbExp=4; IntAct=EBI-1536925, EBI-4434651;
CC Q9FYK5; Q9C5X0: IAA34; NbExp=3; IntAct=EBI-1536925, EBI-3946459;
CC Q9FYK5; Q9FIR9: LSU2; NbExp=3; IntAct=EBI-1536925, EBI-4424076;
CC Q9FYK5; Q9FFJ9: MJJ3.20; NbExp=2; IntAct=EBI-1536925, EBI-15211238;
CC Q9FYK5; Q9LPQ3: MKK7; NbExp=3; IntAct=EBI-1536925, EBI-2128593;
CC Q9FYK5; O22793: MORF2; NbExp=3; IntAct=EBI-1536925, EBI-1998046;
CC Q9FYK5; Q9FX36: MYB54; NbExp=4; IntAct=EBI-1536925, EBI-25511270;
CC Q9FYK5; Q9FUA4: SPT; NbExp=3; IntAct=EBI-1536925, EBI-1536703;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Cotyledons, leaf primordia and shoot apical
CC meristems. {ECO:0000269|PubMed:17056621, ECO:0000269|PubMed:17376809}.
CC -!- DEVELOPMENTAL STAGE: First observed in the embryo at globular stage in
CC cotyledons primordia and later confined to cotyledons tips and shoot
CC apical meristem. Also detected in emerging leaf primordia.
CC {ECO:0000269|PubMed:17056621, ECO:0000269|PubMed:17376809}.
CC -!- MISCELLANEOUS: 'Dornroeschen' means 'Sleeping beauty' in German.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY560889; AAT44956.1; -; mRNA.
DR EMBL; AC000103; AAF97975.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30551.1; -; Genomic_DNA.
DR EMBL; BT026073; ABG48429.1; -; mRNA.
DR RefSeq; NP_173864.1; NM_102301.2.
DR AlphaFoldDB; Q9FYK5; -.
DR SMR; Q9FYK5; -.
DR BioGRID; 24311; 24.
DR IntAct; Q9FYK5; 21.
DR STRING; 3702.AT1G24590.1; -.
DR PaxDb; Q9FYK5; -.
DR PRIDE; Q9FYK5; -.
DR EnsemblPlants; AT1G24590.1; AT1G24590.1; AT1G24590.
DR GeneID; 839073; -.
DR Gramene; AT1G24590.1; AT1G24590.1; AT1G24590.
DR KEGG; ath:AT1G24590; -.
DR Araport; AT1G24590; -.
DR TAIR; locus:2024076; AT1G24590.
DR HOGENOM; CLU_925449_0_0_1; -.
DR InParanoid; Q9FYK5; -.
DR OMA; WADHASG; -.
DR OrthoDB; 1585896at2759; -.
DR PhylomeDB; Q9FYK5; -.
DR PRO; PR:Q9FYK5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FYK5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009880; P:embryonic pattern specification; IMP:TAIR.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; Cytokinin signaling pathway; DNA-binding;
KW Ethylene signaling pathway; Gibberellin signaling pathway; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..306
FT /note="Ethylene-responsive transcription factor ESR2"
FT /id="PRO_0000297928"
FT DNA_BIND 57..114
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 306 AA; 33829 MW; 4B77DFDDC4C4B59A CRC64;
MEEAIMRLEG AEHRETNIHS LKRKPSRTSS TAPGSPGGVT TAKAASGAGA SGVSTIRYRG
VRRRPWGRYA AEIRDPLSKE RRWLGTFDTA EEAACAYDCA ARAMRGLKAR TNFVYPMPSL
DSYHHRIFSS PPMNMFLLRD VLNSQSLSPL TTFAYPPCNL SNVNDVVHES FTNVNDVCED
LSPKAKRSST IENESLISNI FEPEPASSGL LQEIVQGFLP KPISQHASIP PKSNQQSVGV
FPTMPESGFQ TDVRLADFHV EGNGFGQVKY HGELGWADHE NGFDSAKMQQ NGNGGMFYQY
CFHDDY
