ID   ESR2_CHICK              Reviewed;         472 AA.
AC   Q9PTU5;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Estrogen receptor beta;
DE            Short=ER-beta;
DE            Short=cERb;
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 2;
GN   Name=ESR2; Synonyms=NR3A2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Testis;
RA   Suzuki M., Mizuno S., Nakabayashi O.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-alpha,
CC       and activates expression of reporter genes containing estrogen response
CC       elements (ERE) in an estrogen-dependent manner.
CC       {ECO:0000250|UniProtKB:Q92731}.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       alpha.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB036415; BAA88667.1; -; mRNA.
DR   RefSeq; NP_990125.1; NM_204794.2.
DR   AlphaFoldDB; Q9PTU5; -.
DR   SMR; Q9PTU5; -.
DR   STRING; 9031.ENSGALP00000019234; -.
DR   PaxDb; Q9PTU5; -.
DR   GeneID; 395575; -.
DR   KEGG; gga:395575; -.
DR   CTD; 2100; -.
DR   VEuPathDB; HostDB:geneid_395575; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   InParanoid; Q9PTU5; -.
DR   OrthoDB; 487299at2759; -.
DR   PhylomeDB; Q9PTU5; -.
DR   PRO; PR:Q9PTU5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR   GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR021064; ER-beta-like_N.
DR   InterPro; IPR028355; ER-beta/gamma.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF12497; ERbeta_N; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500102; ER-b; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Steroid-binding; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..472
FT                   /note="Estrogen receptor beta"
FT                   /id="PRO_0000053648"
FT   DOMAIN          217..449
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        105..170
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         105..125
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         141..165
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..104
FT                   /note="Modulating"
SQ   SEQUENCE   472 AA;  53439 MW;  A8CBBB8CACA65650 CRC64;
     MAFCSPAMLN YNIASNFGDS ESASVRQTSS PSVLWSAPGH LSPLTLHCQS SLLYAEQPKS
     PWCEVRPLDP VLPVTRETLK RKTNGSDCTS PIASNPGSKR DAHFCAVCSD YASGYHYGVW
     SCEGCKAFFK RSIQGHNDYI CPATNQCTID KNRRKSCQAC RLRKCYEVGM MKCGSRRERC
     GYRILRRHRN SEDCMGKTKK YNEAATRVKE ILLSTVSPEQ FVLTLLEAEP PNVLVSRPSK
     PFTEASMMMS LTKLADKELV HMIGWAKKIP GFIDLSLYDQ VRLLESCWME VLMIGLMWRS
     IDHPGKLIFA PDLVLDRDEG KCVEGILEIF DMLLAMTSRF RELKLQHKEY LCVKAMILLN
     SSMFPLSPEE PESNRKLHHL LNVVTDALVW VIAKSGIPSQ QQTTRLANLL MLLSHVRHAS
     NKGMEHLLSM KCKNVVPVYD LLLEMLNAHT LRGQRKSPVT HPEFEQVSHF QV