ID   ESR2_MACMU              Reviewed;         279 AA.
AC   Q9TTE5;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Estrogen receptor beta;
DE            Short=ER-beta;
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 2;
DE   Flags: Fragment;
GN   Name=ESR2; Synonyms=NR3A2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10644527; DOI=10.1152/ajpcell.2000.278.1.c190;
RA   Wu W.X., Ma X.H., Smith G.C.S., Nathanielsz P.W.;
RT   "Differential distribution of ERalpha and ERbeta mRNA in intrauterine
RT   tissues of the pregnant rhesus monkey.";
RL   Am. J. Physiol. 278:C190-C198(2000).
CC   -!- FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity
CC       similar to that of ESR1/ER-alpha, and activates expression of reporter
CC       genes containing estrogen response elements (ERE) in an estrogen-
CC       dependent manner. {ECO:0000250|UniProtKB:Q92731}.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR1.
CC       Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a
CC       strong increase of transcription of target genes. Interacts with UBE1C
CC       and AKAP13. Interacts with DNTTIP2. Interacts with CCDC62 in the
CC       presence of estradiol/E2; this interaction seems to enhance the
CC       transcription of target genes. Interacts with DNAAF4. Interacts with
CC       PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent
CC       manner. Interacts with RBM39, in the presence of estradiol (E2).
CC       {ECO:0000250|UniProtKB:O08537, ECO:0000250|UniProtKB:Q62986,
CC       ECO:0000250|UniProtKB:Q92731}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92731}.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF119229; AAD54069.1; -; mRNA.
DR   AlphaFoldDB; Q9TTE5; -.
DR   SMR; Q9TTE5; -.
DR   STRING; 9544.ENSMMUP00000030079; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   InParanoid; Q9TTE5; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
DR   GO; GO:0030518; P:intracellular steroid hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   SMART; SM00430; HOLI; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Steroid-binding; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..>279
FT                   /note="Estrogen receptor beta"
FT                   /id="PRO_0000053643"
FT   DOMAIN          27..261
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   NON_TER         1
FT   NON_TER         279
SQ   SEQUENCE   279 AA;  31106 MW;  858D9B7D01DA0301 CRC64;
     QLHCAGKAKR SGSHAPLVRE LLLDALSPEQ LVLTLLEAEP PHVLISRPSA PFTEASMMMS
     LTKLADKELV HMISWAKKIP GFVELSLFDQ VRLLESCWME VLMVGLMWRS IDHPGKLIFA
     PDLVLDRDEG KCVEGILEIF DMLLATTSRF RELKLQHKEY LCVKAMILLN SNMYPLVTAT
     QDADSSRKLA HLLNAVTDAL VWVIAKSGIS SQQQSMRLAN LLMLLSHVRH ASNKGMEHLL
     SMKCKNVVPV YDLLLEMLNA HVLRGCKSSI TGSECSPAE