ID   ESR2_ONCMY              Reviewed;         568 AA.
AC   P57782;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2001, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Estrogen receptor beta;
DE            Short=ER-beta;
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 2;
GN   Name=esr2; Synonyms=nr3a2;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Haugg M., Ackermann G., Fent K.;
RT   "Molecular cloning of an estrogen receptor beta subtype from rainbow
RT   trout.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-alpha,
CC       and activates expression of reporter genes containing estrogen response
CC       elements (ERE) in an estrogen-dependent manner.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-alpha
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AJ289883; CAC06714.1; -; mRNA.
DR   RefSeq; NP_001123457.1; NM_001129985.1.
DR   AlphaFoldDB; P57782; -.
DR   SMR; P57782; -.
DR   PRIDE; P57782; -.
DR   GeneID; 100170205; -.
DR   CTD; 100170205; -.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
DR   GO; GO:1990239; F:steroid hormone binding; IDA:AgBase.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR   GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0032355; P:response to estradiol; IDA:AgBase.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR021064; ER-beta-like_N.
DR   InterPro; IPR028355; ER-beta/gamma.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF12497; ERbeta_N; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500102; ER-b; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Steroid-binding; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..568
FT                   /note="Estrogen receptor beta"
FT                   /id="PRO_0000053656"
FT   DOMAIN          300..536
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        178..243
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         178..198
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         214..238
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..177
FT                   /note="Modulating"
SQ   SEQUENCE   568 AA;  63813 MW;  F7A7BD7B3B2C2804 CRC64;
     MHQQSPVDDV TALNSSALTM SEYPEGESPL QLQDVDSSRV GGHILSPIFN SSSPSLPVES
     HPVCIQSPYT DLGHDFTTLP FYSPALLGYG TSPLSECSSV RQSLSPTLFW PPHSQVSSLA
     LHQQHTRLQQ NHPTGGTWTE LTPHDHSEEE YRKPLVKRVA DAEETSTSLR GKADMHYCAV
     CSDYASGYHY GVWSCEGCKA FFKRSIQGHN DYICPATNQC TIDKNRRKSC QACRLRKCYE
     VGMMKCGLRR DRGSYQQRGA QQKRLARFSG RMRTSGPRSQ EMKSVPCPLS GNEVVNMALT
     PEELIARIMD AEPPEIYLMK DMKKPFTEAN VMMSLTNLAD KELVHMISWA KKVPGFVELS
     LFDQVHLLEC CWLEVLMLGL MWRSVNHPGK LIFSPDLSLS RDEGSCVQGF VEIFDMLLAA
     TSRFRELKLQ REEYVCLKAM ILLNSNMCLS SSEGGEELQR RSKLLCLLDS VTDALVWAIS
     KTGLSFQQRS TRLAHLLMLL SHIRHLSNKG MDHLHCMKMK KMVPLYDLLL EMLDAHIMHG
     SRLSHSGPAP KESTGVQEAT LSVLKNDL