ID   ESR2_ORENI              Reviewed;         557 AA.
AC   Q9YH32;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Estrogen receptor beta;
DE            Short=ER-beta;
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 2;
GN   Name=esr2; Synonyms=nr3a2;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chang X.T., Kobayashi T., Todo T., Yoshiura Y., Ikeuchi T., Kajiura H.,
RA   Nakamura M., Nagahama Y.;
RT   "cDNA sequence of tilapia type beta estrogen receptor.";
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-alpha,
CC       and activates expression of reporter genes containing estrogen response
CC       elements (ERE) in an estrogen-dependent manner.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-alpha
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U75605; AAD00246.1; -; mRNA.
DR   RefSeq; NP_001266703.1; NM_001279774.1.
DR   RefSeq; XP_005475012.1; XM_005474955.3.
DR   AlphaFoldDB; Q9YH32; -.
DR   SMR; Q9YH32; -.
DR   STRING; 8128.ENSONIP00000007090; -.
DR   PRIDE; Q9YH32; -.
DR   Ensembl; ENSONIT00000007095; ENSONIP00000007090; ENSONIG00000005633.
DR   GeneID; 100534515; -.
DR   KEGG; onl:100534515; -.
DR   CTD; 317734; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000156116; -.
DR   HOGENOM; CLU_007368_11_1_1; -.
DR   InParanoid; Q9YH32; -.
DR   OMA; SHKEFSQ; -.
DR   OrthoDB; 487299at2759; -.
DR   Proteomes; UP000005207; Linkage group LG15.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR   GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR021064; ER-beta-like_N.
DR   InterPro; IPR028355; ER-beta/gamma.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF12497; ERbeta_N; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500102; ER-b; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Steroid-binding; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..557
FT                   /note="Estrogen receptor beta"
FT                   /id="PRO_0000053657"
FT   DOMAIN          272..508
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        155..220
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         155..175
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         191..215
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..154
FT                   /note="Modulating"
FT   REGION          240..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..557
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   557 AA;  61780 MW;  82A474988C39CD76 CRC64;
     MMAAASSPEK LLQLQEVDSS RAGSRILSPI LGSSSPGLSH ETSQPICIRS PYTDLGHDFT
     TIPFYSPTIF SYGGPSISEC SSVHQSLSAS LFWPSHGRVG TPITLHCPQG RSQQGQSAQT
     PWDSVITTSK SVRRRSQESE ESMVSSGGKA DLHYCAVCHD YASGYHYGVW SCEGCKAFFK
     RSIQGHNDYI CPATNQCTID KNRRKSCQAC RLRKCYEVGM TKCGIRKERG NYRNSQARRL
     TRLSSQGKTA EPKGITGPAE GSLNKPEKPA LTPEQLIERI LEAEPPEIYL VKDAKRPLTE
     ASVMMLLTNL ADKELVHMIS WAKKIPGFVE LSLVDQVHLL ECCWLEVLMI GLMWRSVDHP
     GKLIFCPDLS LSREEGSCVQ GFVEIFDMLI AATTRVRELK LQREEYVCLK AMILLNSNMC
     LSSSDCSEDL QSRSKLLRLL DAMTDALVLA IGKTGLTFRQ QYTRLAHLLM LLSHIRHVSN
     KGMDHLHCMK MKNIVPLYDL LLEMLDAHIM HSSCLPHQPP QQDSKDQSEV PAPLHSSAGG
     PSNTWTPSSA RAGGESQ