ESR2_PIG
ID ESR2_PIG Reviewed; 526 AA.
AC Q9XSW2; Q9BDW5;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Estrogen receptor beta;
DE Short=ER-beta;
DE AltName: Full=Nuclear receptor subfamily 3 group A member 2;
GN Name=ESR2; Synonyms=NR3A2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RA Kowalski A.A., Graddy L.G., Vale-Cruz D.S., Choi I., Katzenellenbogen B.S.,
RA Simmen F.A., Simmen R.C.M.;
RT "Molecular cloning of porcine estrogen receptor beta cDNAs and
RT developmental expression in peri-implantation embryos.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RA LaVoie H.A., DeSimone D.C.;
RT "Cloning and expression of estrogen receptor beta isoforms from porcine
RT ovary.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity
CC similar to that of ESR1/ER-alpha, and activates expression of reporter
CC genes containing estrogen response elements (ERE) in an estrogen-
CC dependent manner. {ECO:0000250|UniProtKB:Q92731}.
CC -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR1.
CC Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a
CC strong increase of transcription of target genes. Interacts with UBE1C
CC and AKAP13. Interacts with DNTTIP2. Interacts with CCDC62 in the
CC presence of estradiol/E2; this interaction seems to enhance the
CC transcription of target genes. Interacts with DNAAF4. Interacts with
CC PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent
CC manner. Interacts with RBM39, in the presence of estradiol (E2).
CC {ECO:0000250|UniProtKB:O08537, ECO:0000250|UniProtKB:Q62986,
CC ECO:0000250|UniProtKB:Q92731}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92731}.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- PTM: Phosphorylation at Ser-84 and Ser-102 recruits NCOA1.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000305}.
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DR EMBL; AF164957; AAD45381.2; -; mRNA.
DR EMBL; AF267736; AAK15151.1; -; mRNA.
DR RefSeq; NP_001001533.1; NM_001001533.1.
DR AlphaFoldDB; Q9XSW2; -.
DR SMR; Q9XSW2; -.
DR STRING; 9823.ENSSSCP00000005491; -.
DR PaxDb; Q9XSW2; -.
DR GeneID; 396697; -.
DR KEGG; ssc:396697; -.
DR CTD; 2100; -.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q9XSW2; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR021064; ER-beta-like_N.
DR InterPro; IPR028355; ER-beta/gamma.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF12497; ERbeta_N; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500102; ER-b; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Lipid-binding; Metal-binding; Nucleus;
KW Phosphoprotein; Receptor; Reference proteome; Steroid-binding;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..526
FT /note="Estrogen receptor beta"
FT /id="PRO_0000053645"
FT DOMAIN 261..494
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 146..211
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 146..166
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 182..206
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..145
FT /note="Modulating"
FT REGION 502..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphoserine; by MAPK"
FT /evidence="ECO:0000250|UniProtKB:O08537"
FT MOD_RES 102
FT /note="Phosphoserine; by MAPK"
FT /evidence="ECO:0000250|UniProtKB:O08537"
FT CONFLICT 317
FT /note="M -> V (in Ref. 2; AAK15151)"
FT /evidence="ECO:0000305"
FT CONFLICT 469
FT /note="T -> M (in Ref. 2; AAK15151)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 526 AA; 58850 MW; 35CE2DF661078BF6 CRC64;
MDIKNSPSNL NSPVSYNCSQ SVLPLEPGPI YIPSSYVESC HEYSAMTFYS PAVVNYSISS
NSEVGPGRQA TSPNVLWPTP GHLSPLAIHC QPSLLYAEPQ KSPWCDTRSL EHTLPVNRET
LKRKASGSSC ASPVTSPSSK RDAHFCAVCS DYASGYHYGV WSCEGCKAFF KRSIQGHNDY
ICPATNQCTI DKNRRKSCQA CRLRKCYEVG MVKCGSRRER CGYRIVRKQR NSEGHLHCLS
RAKKNGDHTT RVKELLLSTL SPEQLVLTLL EAEPPHVLVS RPSTPFTEAS MMMSLTKLAD
KELVHMISWA KKIPGFMELS LYDQVRLLES CWLEVLMVGL MWRSIDHPGK LIFAPDLVLD
RDEGKCVEGI LEIFDMLLAT TSRFRELKLQ HKEYLCVKAM ILLNSSMYPS AAAQEAESSR
KLTHLLNAVT DALVWVIARS GISSQQQSVR LANLLMLLSH VRHASNKGTE HLLNMKCKNV
VPVYDLLLEM LNAHTLRGNK SLVTGSERSR MEESESKEGS QKPQAQ
