ESR3_MICUN
ID ESR3_MICUN Reviewed; 565 AA.
AC P57783;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Estrogen receptor gamma;
DE Short=ER-gamma;
DE AltName: Full=Nuclear receptor subfamily 3 group A member 3;
GN Name=esr3; Synonyms=nr3a3;
OS Micropogonias undulatus (Atlantic croaker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Micropogonias.
OX NCBI_TaxID=29154;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=11005855; DOI=10.1073/pnas.97.20.10751;
RA Hawkins M.B., Thornton J.W., Crews D., Skipper J.K., Dotte A., Thomas P.;
RT "Identification of a third distinct estrogen receptor and reclassification
RT of estrogen receptors in teleosts.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:10751-10756(2000).
CC -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC regulation of eukaryotic gene expression and affect cellular
CC proliferation and differentiation in target tissues.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Abundant in the ovary and testes, barely detectable
CC in the brain and muscle and undetectable in the liver.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC DNA-binding domain and a C-terminal ligand-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000305}.
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DR EMBL; AF298182; AAG16712.1; -; mRNA.
DR AlphaFoldDB; P57783; -.
DR SMR; P57783; -.
DR PRIDE; P57783; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042562; F:hormone binding; IEA:UniProt.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR021064; ER-beta-like_N.
DR InterPro; IPR028355; ER-beta/gamma.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF12497; ERbeta_N; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500102; ER-b; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW Steroid-binding; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..565
FT /note="Estrogen receptor gamma"
FT /id="PRO_0000053659"
FT DOMAIN 286..516
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 169..234
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 169..189
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 205..229
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..168
FT /note="Modulating"
FT REGION 235..285
FT /note="Hinge"
FT REGION 522..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 62903 MW; D9954D2F740CCA5E CRC64;
MAVASSPEKD QPLLQLQKVD SSRVGGQVLS PTLSSSLETS QPICITSPYT DLGHDFPTIP
FYSPTIFSYA GPSISDCTSV HQSLNPSLFW PSRGHMGSPI PLHHSQHGQP IQSPWVEISP
LDNVLKTKQD GASLPLAVVP VRHKSARRRS QESEEAVVTS GGKTDLHYCA VCHDYASGYH
YGVWSCEGCK AFFKRSIQRD NEYICPATNE CTIDKNRRKS CQACRLRKCY EVGMTKCGMR
KERGNYRSPQ MRRMTRLTSQ GRTDSSSVLT GSAVVSLNAP QPSALTSEQL IERLMEAEPP
EIYLMKDMKK PLTEAKVMMS LTNLADKELV HMITWAKKIP GFVELGLLDQ VHLLECCWLE
VLMVGLMWRS VDHPGKLVFS PDLSLSREEG SCVQGFAEIF DMLLAATSRV RELKLQREEY
VCLKAMILLN SNMCLSSSES SSKLLRLLDA VTDALVSAIG KTVLSFRQQY TRLAHLLMLL
SHIRHVSNKG MDHLHCMKMK NMVPLYDLLL EMLDAHIMHS SRLPRRSPEQ EPEDQADAPA
PPHSSGSGPS YTWTPSSSEG AGEPQ
