ESRG_HUMAN
ID ESRG_HUMAN Reviewed; 222 AA.
AC Q1W209;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2013, sequence version 2.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Embryonic stem cell-related gene protein;
DE Short=hES cell-related gene protein;
GN Name=ESRG; Synonyms=HESRG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryonic stem cell;
RX PubMed=17803967; DOI=10.1016/j.bbrc.2007.08.081;
RA Zhao M., Ren C., Yang H., Feng X., Jiang X., Zhu B., Zhou W., Wang L.,
RA Zeng Y., Yao K.;
RT "Transcriptional profiling of human embryonic stem cells and embryoid
RT bodies identifies HESRG, a novel stem cell gene.";
RL Biochem. Biophys. Res. Commun. 362:916-922(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], NON-AUG INITIATOR START CODON, TISSUE
RP SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=23628413; DOI=10.1016/j.bbrc.2013.04.062;
RA Li G., Ren C., Shi J., Huang W., Liu H., Feng X., Liu W., Zhu B., Zhang C.,
RA Wang L., Yao K., Jiang X.;
RT "Identification, expression and subcellular localization of ESRG.";
RL Biochem. Biophys. Res. Commun. 435:160-164(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23628413}.
CC -!- TISSUE SPECIFICITY: Expressed only in fetal ovary and in
CC undifferentiated ES cells. {ECO:0000269|PubMed:17803967,
CC ECO:0000269|PubMed:23628413}.
CC -!- INDUCTION: Down-regulated during differentiation of ES cells.
CC {ECO:0000269|PubMed:17803967}.
CC -!- CAUTION: The initiator methionine is coded by a non-canonical CTG
CC leucine codon. {ECO:0000305|PubMed:23628413}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABD92927.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; DQ445779; ABD92927.1; ALT_SEQ; mRNA.
DR EMBL; AC092057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q1W209; -.
DR BioMuta; HGNC:39079; -.
DR MassIVE; Q1W209; -.
DR PeptideAtlas; Q1W209; -.
DR PRIDE; Q1W209; -.
DR GeneCards; ESRG; -.
DR HGNC; HGNC:39079; ESRG.
DR MIM; 611473; gene.
DR neXtProt; NX_Q1W209; -.
DR InParanoid; Q1W209; -.
DR Pharos; Q1W209; Tdark.
DR PRO; PR:Q1W209; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q1W209; protein.
DR GO; GO:0005634; C:nucleus; IDA:CACAO.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..222
FT /note="Embryonic stem cell-related gene protein"
FT /id="PRO_0000323559"
FT CONFLICT 70
FT /note="L -> P (in Ref. 1; ABD92927)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="S -> F (in Ref. 2; no nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 222 AA; 24186 MW; C4F240F177FBA93F CRC64;
MTLFSDSARL HPGEINSLVA HTKPVWWSLH TDAHEIWCRD SDRGTSLGRS IPCPPALCSV
RKIHLRPQVL RPTSPRNISP ISNPVSGLFL LCSPTSLTIP QPLSPFNLGA TLQSLPSLNF
NSFHSLVETK ETCFIREPKT PAPVTDWEGS LPLVFNHCRD ASLISRFRPR RDACLGPSPL
AASPAFLGQG QVPLNPFSFT LSGKSRFSGA GASTPQPLLL HP
