ID   ESRP1_XENLA             Reviewed;         688 AA.
AC   Q7ZY29;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Epithelial splicing regulatory protein 1;
DE   AltName: Full=RNA-binding motif protein 35A;
DE   AltName: Full=RNA-binding protein 35A;
GN   Name=esrp1; Synonyms=rbm35a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: mRNA splicing factor that regulates the formation of
CC       epithelial cell-specific isoforms. Specifically regulates the
CC       expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2.
CC       Acts by directly binding specific sequences in mRNAs. Binds the GU-rich
CC       sequence motifs in the ISE/ISS-3, a cis-element regulatory region
CC       present in the mRNA of fgfr2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESRP family. {ECO:0000305}.
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DR   EMBL; BC044002; AAH44002.1; -; mRNA.
DR   RefSeq; NP_001079524.1; NM_001086055.1.
DR   AlphaFoldDB; Q7ZY29; -.
DR   SMR; Q7ZY29; -.
DR   MaxQB; Q7ZY29; -.
DR   DNASU; 379211; -.
DR   GeneID; 379211; -.
DR   KEGG; xla:379211; -.
DR   CTD; 379211; -.
DR   Xenbase; XB-GENE-985143; esrp1.L.
DR   OrthoDB; 376996at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 379211; Expressed in zone of skin and 15 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12736; RRM1_ESRP1; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034427; ESRP1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..688
FT                   /note="Epithelial splicing regulatory protein 1"
FT                   /id="PRO_0000273048"
FT   DOMAIN          226..303
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          327..407
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          446..526
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   688 AA;  76426 MW;  39E119270E829A9D CRC64;
     MTAVSPDYLV VLFTTTAGAN GSKLGSDEKE VIQLLWKVIN LANKKVGELH EVTVRPDHLE
     LTEECKEITQ IETDDLYVAP QLEQALQQFN QSVGNELNIG VGTSFCICTD GQLHVRQVLH
     PEASKKNILL PECFYSFFDL RKEFMKCCPG SSDINELDVH AMASFLGFEK KNTHYRYGAS
     EVDDMGDIIV TLISEPYNYK FSDPERVNYK FESGTCSKLE MIDDNTIIRA RGLPWQSSDQ
     DIARFFKGLN IAKGGAALCL NAQGRRNGEA LVRFVSEEHR DLALQRHKHH MGNRYIEVYK
     ATGEDFLKIA GGTSNEVAQF LSKENQVIVR MRGLPFTATA EEVLAFFGQQ CPVTGGKEGI
     LFVTYPDNRP TGDAFVLFAC EEYAQNALKK HKELLGKRYI ELFRSTAAEV QQVLNRYSSA
     PLIPLPTPPI IPVLPQPFIP PVNVRDCIRL RGLPYAATIE DILEFLGEFS ADIRTHGVHM
     VLNHQGRPSG DSFIQMKSAD RAYLAAQKCH KKTMKDRYVE VFQCSAEEMN FVLMGGTLNR
     NGLSPPPCKL PCLSPPSYTF PAQAAVIPTE AAALYQPSLL LNPRSLQPSA AAYYPAGAQL
     FMNYTAYYPS PPGSPSSLGF FPASAGVSTM PPHNTGAMVR MQGLAYNSGV KDILNFFQGY
     QYSPEDGLLP VNDQARALLT HPKEWVCI