ID   ESRP1_XENTR             Reviewed;         687 AA.
AC   Q6DEZ7;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Epithelial splicing regulatory protein 1;
DE   AltName: Full=RNA-binding motif protein 35A;
DE   AltName: Full=RNA-binding protein 35A;
GN   Name=esrp1; Synonyms=rbm35a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: mRNA splicing factor that regulates the formation of
CC       epithelial cell-specific isoforms. Specifically regulates the
CC       expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2.
CC       Acts by directly binding specific sequences in mRNAs. Binds the GU-rich
CC       sequence motifs in the ISE/ISS-3, a cis-element regulatory region
CC       present in the mRNA of fgfr2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESRP family. {ECO:0000305}.
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DR   EMBL; BC076946; AAH76946.1; -; mRNA.
DR   RefSeq; NP_001005057.1; NM_001005057.1.
DR   AlphaFoldDB; Q6DEZ7; -.
DR   SMR; Q6DEZ7; -.
DR   STRING; 8364.ENSXETP00000059731; -.
DR   PaxDb; Q6DEZ7; -.
DR   DNASU; 448608; -.
DR   Ensembl; ENSXETT00000032125; ENSXETP00000032125; ENSXETG00000014667.
DR   GeneID; 448608; -.
DR   KEGG; xtr:448608; -.
DR   CTD; 54845; -.
DR   Xenbase; XB-GENE-985138; esrp1.
DR   eggNOG; KOG1365; Eukaryota.
DR   InParanoid; Q6DEZ7; -.
DR   OrthoDB; 376996at2759; -.
DR   PhylomeDB; Q6DEZ7; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014667; Expressed in neurula embryo and 14 other tissues.
DR   ExpressionAtlas; Q6DEZ7; differential.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12736; RRM1_ESRP1; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034427; ESRP1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..687
FT                   /note="Epithelial splicing regulatory protein 1"
FT                   /id="PRO_0000273049"
FT   DOMAIN          226..303
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          327..407
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          446..526
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   687 AA;  76311 MW;  2EC289AC1CABDFF2 CRC64;
     MTAVSPDYLV VLFTTTAGAN GSKLGSDEKE VIQLLWKVIN LANKKVGELH EVTVRPDHLE
     LTEECKEITR IEADSLYVAP QLEQALQQFN QSVGNELNIG VGTSFCICTD GQLHIRQVLH
     PEASKKNILL PECFYSFFDL RKEFLKCCPG SSDTNELDVH AMASYLGFEK KSTRYRYGAS
     EVDDMGDIIV TLISEPYNYK FSDPERVNYK FESGTCSKLE IIDDNTIIRA RGLPWQSSDQ
     DIARFFKGLN IAKGGAALCL NAQGRRNGEA LVRFVSEEHR DLALQRHKHH MGNRYIEVYK
     ATGEDFLKIA GGTSNEVAQF LSKENQVIVR MRGLPFTATA EEVLAFFGQQ CPVTGGKEGI
     LFVTYPDNRP TGDAFVLFAC EEYAQNALKK HKELLGKRYI ELFRSTAAEV QQVLNRYSSA
     PLIPLPTPPI IPVLPQPFIP PVNVRDCIRL RGLPYAATIE DILEFLGEFS ADIRTHGVHM
     VLNHQGRPSG DSFIQMKSAD RAYLAAQKCH KKTMKDRYVE VFQCSAEEMN FVLMGGTLNR
     NGLSPPPCKL PCLSPPSYTF PAQAAVIPTE AAALYQPSLL LNPRSLQPSA AYYPAGAQLF
     MNYTAYYPSP PGSPSSLGFF PASASVSSIP PHNTGAMVRM QGLAYNSGVK EILNFFQGYQ
     YSPEDGLLPV NDQARALLTH PKEWVCI