ID   ESRP2_CHICK             Reviewed;         701 AA.
AC   Q5ZLR4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Epithelial splicing regulatory protein 2;
DE   AltName: Full=RNA-binding motif protein 35B;
DE   AltName: Full=RNA-binding protein 35B;
GN   Name=ESRP2; Synonyms=RBM35B; ORFNames=RCJMB04_5c3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: mRNA splicing factor that regulates the formation of
CC       epithelial cell-specific isoforms. Specifically regulates the
CC       expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.
CC       Acts by directly binding specific sequences in mRNAs. Binds the GU-rich
CC       sequence motifs in the ISE/ISS-3, a cis-element regulatory region
CC       present in the mRNA of FGFR2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESRP family. {ECO:0000305}.
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DR   EMBL; AJ719670; CAG31329.1; -; mRNA.
DR   RefSeq; NP_001025737.1; NM_001030566.1.
DR   AlphaFoldDB; Q5ZLR4; -.
DR   SMR; Q5ZLR4; -.
DR   STRING; 9031.ENSGALP00000005323; -.
DR   PaxDb; Q5ZLR4; -.
DR   Ensembl; ENSGALT00000005333; ENSGALP00000005323; ENSGALG00000003374.
DR   GeneID; 415710; -.
DR   KEGG; gga:415710; -.
DR   CTD; 80004; -.
DR   VEuPathDB; HostDB:geneid_415710; -.
DR   eggNOG; KOG1365; Eukaryota.
DR   GeneTree; ENSGT00940000157187; -.
DR   HOGENOM; CLU_008009_2_1_1; -.
DR   InParanoid; Q5ZLR4; -.
DR   PhylomeDB; Q5ZLR4; -.
DR   TreeFam; TF316157; -.
DR   Reactome; R-GGA-6803529; FGFR2 alternative splicing.
DR   PRO; PR:Q5ZLR4; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000003374; Expressed in colon and 5 other tissues.
DR   ExpressionAtlas; Q5ZLR4; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR034431; ESRP2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR13976:SF30; PTHR13976:SF30; 1.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..701
FT                   /note="Epithelial splicing regulatory protein 2"
FT                   /id="PRO_0000273052"
FT   DOMAIN          226..303
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          327..407
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          448..523
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   701 AA;  76947 MW;  64877F1D28CE362D CRC64;
     MTASHSDSLV VLFGATAGAY GAKLGSDERE LILLVWQVVD LPSKKVGTLH KSLVKADNLE
     LSDQCREVSG LTAEGLGKAE PLDRVLQQFI QLVSSDLKVF GRNSYTLCSD GQLLIRQVLH
     PETSKKNFLL SDCFYSFYDL RKEFHTCYPS SAAVKDQTIK TMAEYLGLGT DEAEEDFGVW
     QVKTMVAIIF SMLSENCDHI FTDPETVKYK YETGPCSKSE TVDSETVIRA RGLPWQSSDQ
     DIARFFKGLN IAKGGVALCL NAQGRRNGEA LVRFVNSEQR DLALERHKHH MGSRYIEVYK
     ATGEEFLKIA GGTSNEVAQF LSKENQVIIR MRGLPFTATQ EDVLGFLGPE CPVTGGKEGL
     LFVKYPDGRP TGDAFVLFSC EEYAQNALKK HKEILGKRYI ELFRSTAAEV QQVLNRYMST
     PLIPTLPTPI IPVIPPPYTI ATGSIRDCVR LRGLPYTAGI DDILDFMGDA TADIKPHGVH
     MVLNQQGRPS GDAFIQMKSA DKAFMVAQKC HKKMMKDRYV EVFQCSGEEM NFVLMGGTLN
     RSGLSPPPCL SPPAYAAFQT AAVIPAEAAL YQPQALLPTA RTPQASAAAP PAVTYYPAQA
     AQLYMNYTAY YPSPPVSPTT VGYLAAPPGA VAAAATATHT PLLPQPGALV RMQGLPYNTG
     MKEILSFFQG YQYAPDDYNG LIQLSEQARS VLQAPKEWVC L