ESRP2_DANRE
ID ESRP2_DANRE Reviewed; 736 AA.
AC Q7ZVR8; Q6P0A9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Epithelial splicing regulatory protein 2;
DE AltName: Full=RNA-binding motif protein 35B;
DE AltName: Full=RNA-binding protein 35B;
GN Name=esrp2; Synonyms=rbm35b; ORFNames=zgc:77254;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=AB; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: mRNA splicing factor that regulates the formation of
CC epithelial cell-specific isoforms. Specifically regulates the
CC expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2.
CC Acts by directly binding specific sequences in mRNAs. Binds the GU-rich
CC sequence motifs in the ISE/ISS-3, a cis-element regulatory region
CC present in the mRNA of fgfr2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7ZVR8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7ZVR8-2; Sequence=VSP_023999;
CC -!- SIMILARITY: Belongs to the ESRP family. {ECO:0000305}.
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DR EMBL; BC045439; AAH45439.1; -; mRNA.
DR EMBL; BC065688; AAH65688.1; -; mRNA.
DR RefSeq; NP_954966.1; NM_199272.1.
DR AlphaFoldDB; Q7ZVR8; -.
DR SMR; Q7ZVR8; -.
DR STRING; 7955.ENSDARP00000015568; -.
DR PaxDb; Q7ZVR8; -.
DR GeneID; 572992; -.
DR KEGG; dre:572992; -.
DR CTD; 80004; -.
DR ZFIN; ZDB-GENE-030131-9824; esrp2.
DR eggNOG; KOG1365; Eukaryota.
DR InParanoid; Q7ZVR8; -.
DR OrthoDB; 376996at2759; -.
DR PhylomeDB; Q7ZVR8; -.
DR Reactome; R-DRE-6803529; FGFR2 alternative splicing.
DR PRO; PR:Q7ZVR8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.10; -; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR034431; ESRP2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13976:SF30; PTHR13976:SF30; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF54928; SSF54928; 3.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..736
FT /note="Epithelial splicing regulatory protein 2"
FT /id="PRO_0000273054"
FT DOMAIN 224..301
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 325..405
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 659..736
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VAR_SEQ 685..736
FT /note="QADSVLVLYNWSGQRSGEALVTFPSEKAARRAVAECSNIPLSGHPIHLACCE
FT -> NPEDYSSLVGVSDQGRSFIQPKEWLCL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_023999"
FT CONFLICT 159
FT /note="L -> P (in Ref. 1; AAH65688)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="Q -> R (in Ref. 1; AAH45439)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="D -> E (in Ref. 1; AAH65688)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="A -> S (in Ref. 1; AAH65688)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="F -> L (in Ref. 1; AAH45439)"
FT /evidence="ECO:0000305"
FT CONFLICT 577
FT /note="A -> G (in Ref. 1; AAH45439)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 736 AA; 80830 MW; 7B8E1E660CAF2EC6 CRC64;
MASHSDTLVV FFGATAGANG GKLGSDEREL ILLVWQIVDL HENKVGKLHR TLVQPDSVDL
SEQCKEETGL TAEELCKAEP LESVLQQFHQ SVSAELKSLG RSSYTLCVDG PLLIRQVLHP
EASKKNLVLP ECFYTFVDLK KEFHKCCPNA GPVKDLTLLS MLDYVCIQAT VEQEAGLREV
KDMVLLILHV LADPYNHKFS AFETVNYKFE SGACSKTEAV DSETVIRARG LPWQSSDQDI
ARFFKGLNIA KGGVALCLNA QGRRNGEALV RFINSEHRDM ALDRHKHHMG SRYIEVYKAT
GEEFLKIAGG TSNEVAQFLS KENQMIIRMR GLPFTATPQD VLGFLGPECP VTDGTEGLLF
VKYPDGRPTG DAFVLFACEE YAQNALKKHK QILGKRYIEL FRSTAAEVQQ VLNRYMSTPL
ISTLPPPPPP MVSVPVLATP PFITTGNTRD CIRLRGLPYT AAIEDILEFM GEHTIDIKPH
GVHMVLNQQG RPSGDAFIQM KSADRAFMVA QKCHKKMMKD RYVEVFQCST EEMSFVLMGG
TLNRSGLSPP PCKLPCLSPP TYAAFPAAPA MLPTEAALYQ PPLLATPRTP QAPTHSPAPA
FAYYSPQLYM NMNMSYTTYY PSPPVSPSTV SYFAAPPGSV AAAVAAQPTP AILPPQPGAL
VRMQGLPYNA GVKDILSFFQ GYQLQADSVL VLYNWSGQRS GEALVTFPSE KAARRAVAEC
SNIPLSGHPI HLACCE
