ESS2_CAEEL
ID ESS2_CAEEL Reviewed; 531 AA.
AC P34420; Q6AHR6;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Splicing factor ESS-2 {ECO:0000303|PubMed:25194163};
DE AltName: Full=ES2 similar protein 2;
GN Name=ess-2; ORFNames=F42H10.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP SIMILARITY.
RX PubMed=8703114; DOI=10.1007/s003359900197;
RA Rizzu P., Lindsay E.A., Taylor C., O'Donnell H., Levy A., Scambler P.J.,
RA Baldini A.;
RT "Cloning and comparative mapping of a gene from the commonly deleted region
RT of DiGeorge and Velocardiofacial syndromes conserved in C. elegans.";
RL Mamm. Genome 7:639-643(1996).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=25194163; DOI=10.1534/genetics.114.167841;
RA Noma K., Goncharov A., Jin Y.;
RT "Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA
RT splicing in Caenorhabditis elegans.";
RL Genetics 198:1101-1115(2014).
CC -!- FUNCTION: Regulates pre-mRNA splicing. {ECO:0000269|PubMed:25194163}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25194163}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=P34420-1; Sequence=Displayed;
CC Name=a;
CC IsoId=P34420-2; Sequence=VSP_015951;
CC -!- SIMILARITY: Belongs to the ESS2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080327; CCD62885.1; -; Genomic_DNA.
DR EMBL; FO080327; CCD62886.1; -; Genomic_DNA.
DR PIR; S44649; S44649.
DR RefSeq; NP_001022580.1; NM_001027409.3. [P34420-2]
DR RefSeq; NP_001022581.1; NM_001027410.3. [P34420-1]
DR AlphaFoldDB; P34420; -.
DR BioGRID; 41404; 14.
DR DIP; DIP-25557N; -.
DR IntAct; P34420; 11.
DR MINT; P34420; -.
DR STRING; 6239.F42H10.7b; -.
DR iPTMnet; P34420; -.
DR EPD; P34420; -.
DR PaxDb; P34420; -.
DR PeptideAtlas; P34420; -.
DR PRIDE; P34420; -.
DR EnsemblMetazoa; F42H10.7a.1; F42H10.7a.1; WBGene00018371. [P34420-2]
DR EnsemblMetazoa; F42H10.7b.1; F42H10.7b.1; WBGene00018371. [P34420-1]
DR GeneID; 176200; -.
DR KEGG; cel:CELE_F42H10.7; -.
DR UCSC; F42H10.7b; c. elegans. [P34420-1]
DR CTD; 176200; -.
DR WormBase; F42H10.7a; CE00169; WBGene00018371; ess-2. [P34420-2]
DR WormBase; F42H10.7b; CE37109; WBGene00018371; ess-2. [P34420-1]
DR eggNOG; KOG2627; Eukaryota.
DR GeneTree; ENSGT00390000009387; -.
DR InParanoid; P34420; -.
DR OMA; PFANEEG; -.
DR OrthoDB; 1378245at2759; -.
DR PhylomeDB; P34420; -.
DR SignaLink; P34420; -.
DR PRO; PR:P34420; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00018371; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR InterPro; IPR019148; Nuclear_protein_DGCR14_ESS-2.
DR PANTHER; PTHR12940; PTHR12940; 1.
DR Pfam; PF09751; Es2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..531
FT /note="Splicing factor ESS-2"
FT /id="PRO_0000079874"
FT REGION 104..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 412..413
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_015951"
SQ SEQUENCE 531 AA; 58519 MW; 809E5BA29DC4173D CRC64;
MSSFDKNDER AQLMVPKSIN EGKVVKLSQK TLVTKKIERQ VVPEEKYIAG LDKIIEKDYF
PHLKKMQAQK EYLEAVANKD INKIKELQMK FCSTGSVRTD RSFRTPITTR STTEAPDVSS
FDADTPGPSS ASTSSAHDWM QSPMPFANEE GDNEALNRKR KKKKEETLTS YLNKYTSEDN
ASFEELAKVM REREDARRPW VYKAEEEHNK NLVTRQAIAA EADVQLALKH AVDADDNRPL
NVDNWAYKAW NTVLFNPDGA ALTPAEIADA ARKQQTEINK RGTRFPDSGK LKPSDEAMTR
AAVSHALANA GKVDFLGNEV TPANSFKLLE TPNPNPDDMD SPLMTWGEID GTPFRLDAPD
VTEHSLPGAA PVFKIPEVPY REKIAQSMND SIAAKYRDKR KVAMRAAEGA HFSRTPGFGS
KRVSDKLAQL SPAAQKLATK KLGLKMLPAH KSPFASPKIM SNWSRPSSSK RSTTPGSAWS
RGSTTPGSSW SQGAQTPGTP GIESMIRRKG DNVGPSTSAG AADRANAGDF F
