ESS2_DROME
ID ESS2_DROME Reviewed; 501 AA.
AC O44424; Q8T9F3; Q9W3F2;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Splicing factor ESS-2 homolog;
DE AltName: Full=Protein Es2;
DE AltName: Full=dEs2;
GN Name=Es2; ORFNames=CG1474;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAL39937.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 88-501.
RC TISSUE=Embryo;
RX PubMed=9499415; DOI=10.1093/hmg/7.4.629;
RA Lindsay E.A., Harvey E.L., Scambler P.J., Baldini A.B.;
RT "ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is
RT expressed during early mouse development, where it shares an expression
RT domain with a Goosecoid-like gene.";
RL Hum. Mol. Genet. 7:629-635(1998).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409 AND SER-411, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P34420}.
CC -!- SIMILARITY: Belongs to the ESS2 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF46375.1; -; Genomic_DNA.
DR EMBL; AY069792; AAL39937.1; -; mRNA.
DR EMBL; AF037257; AAC04785.1; -; mRNA.
DR RefSeq; NP_572480.1; NM_132252.5.
DR AlphaFoldDB; O44424; -.
DR BioGRID; 58239; 33.
DR DIP; DIP-18468N; -.
DR IntAct; O44424; 9.
DR STRING; 7227.FBpp0071145; -.
DR iPTMnet; O44424; -.
DR PaxDb; O44424; -.
DR DNASU; 31780; -.
DR EnsemblMetazoa; FBtr0071198; FBpp0071145; FBgn0023506.
DR GeneID; 31780; -.
DR KEGG; dme:Dmel_CG1474; -.
DR UCSC; CG1474-RA; d. melanogaster.
DR CTD; 109579; -.
DR FlyBase; FBgn0023506; Es2.
DR VEuPathDB; VectorBase:FBgn0023506; -.
DR eggNOG; KOG2627; Eukaryota.
DR GeneTree; ENSGT00390000009387; -.
DR HOGENOM; CLU_024820_0_1_1; -.
DR InParanoid; O44424; -.
DR OMA; AQNDYLD; -.
DR OrthoDB; 1378245at2759; -.
DR PhylomeDB; O44424; -.
DR SignaLink; O44424; -.
DR BioGRID-ORCS; 31780; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31780; -.
DR PRO; PR:O44424; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0023506; Expressed in egg cell and 20 other tissues.
DR ExpressionAtlas; O44424; baseline and differential.
DR Genevisible; O44424; DM.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IC:FlyBase.
DR GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR InterPro; IPR019148; Nuclear_protein_DGCR14_ESS-2.
DR PANTHER; PTHR12940; PTHR12940; 1.
DR Pfam; PF09751; Es2; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..501
FT /note="Splicing factor ESS-2 homolog"
FT /id="PRO_0000079875"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 409
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 411
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 142
FT /note="R -> W (in Ref. 3; AAL39937)"
FT /evidence="ECO:0000305"
FT CONFLICT 166..167
FT /note="KL -> NV (in Ref. 4; AAC04785)"
FT /evidence="ECO:0000305"
FT CONFLICT 381..383
FT /note="RNQ -> PNP (in Ref. 4; AAC04785)"
FT /evidence="ECO:0000305"
FT CONFLICT 469
FT /note="S -> N (in Ref. 4; AAC04785)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 56019 MW; 796B217E368AB78F CRC64;
MSATTRTPAT PGTPGTPGSL AMEVARVQNS ALAEFKKPTA MVRHKNKPKI LTEEKYIEEM
SKIIQRDFFP DLERLRAQND YLDAESRRDF VQMAEIRERY SLGRISGTGR STSRRNNAMS
PATFETPVSQ AKCSNTPLPN SRATDTPFST DGSEKSDAEG RDTTAKLSLD AFLQKYTSED
NQSFQEIIET AEAKLRQKYA VLYNHEKLSA EQLQRALMLP SIETQFEEPD PLRKIETWNY
TNMNSIMYVP DGVEYTEEER VQLAERKQSI QHNATRLPDE AKHREMDTKK LNDEVPQNGA
GGATATPKVR GFDLLRSPSP RPGEAFSPIM TWGEIDGTPF RLDGGDTPLR PTQGPSFRIN
ENSRRENIAI ALAERVSERM RNQKQMALDT ARRNIGSPLI RTNMERLASM SPAAQLLATG
KLGIRGTPRL RHTPSPMSGR KRKVTPGVVR STNTPILGEP KPKQQAKIST PAKNVTIDTG
STLTDDLLKI PTKRRTAADF F
