ID   ESSA_STAAE              Reviewed;         152 AA.
AC   P0C052; A0A0H3K5X0;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=ESAT-6 secretion machinery protein EssA {ECO:0000305};
GN   Name=essA {ECO:0000303|PubMed:15657139};
GN   OrderedLocusNames=NWMN_0221 {ECO:0000312|EMBL:BAF66493.1};
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Newman;
RX   PubMed=15657139; DOI=10.1073/pnas.0405620102;
RA   Burts M.L., Williams W.A., DeBord K., Missiakas D.M.;
RT   "EsxA and EsxB are secreted by an ESAT-6-like system that is required for
RT   the pathogenesis of Staphylococcus aureus infections.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:1169-1174(2005).
CC   -!- FUNCTION: Component of the ESAT-6 secretion system (Ess) (Probable).
CC       Required for the secretion of EsxA and EsxB (PubMed:15657139).
CC       {ECO:0000269|PubMed:15657139, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15657139};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Mutations abolish synthesis and secretion of both
CC       EsxA and EsxB, without affecting their transcription.
CC       {ECO:0000269|PubMed:15657139}.
CC   -!- SIMILARITY: Belongs to the EssA family. {ECO:0000305}.
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DR   EMBL; AP009351; BAF66493.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0C052; -.
DR   EnsemblBacteria; BAF66493; BAF66493; NWMN_0221.
DR   KEGG; sae:NWMN_0221; -.
DR   HOGENOM; CLU_144832_0_0_9; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR034026; EssA.
DR   InterPro; IPR018920; EssA/YueC.
DR   Pfam; PF10661; EssA; 1.
DR   TIGRFAMs; TIGR03927; T7SS_EssA_Firm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..152
FT                   /note="ESAT-6 secretion machinery protein EssA"
FT                   /id="PRO_0000019574"
FT   TOPO_DOM        1..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:15657139"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305|PubMed:15657139"
SQ   SEQUENCE   152 AA;  17451 MW;  6C813CF5F1A6DA31 CRC64;
     MLMNSVIALT FLTASSNNGG LNIDVQQEEE KRINNDLNQY DTTLFNKDSK EVNDAIAKQK
     KERQQQIKND MFQNQASHST RLNETKKVLF SKSNLEKTSE SDKSPYIQNK QEKKIFPYIL
     MSVGAFLTLG FVIFSIHKGR RTKNESARKS NI