ID   ESSA_STAAM              Reviewed;         152 AA.
AC   Q99WU2;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=ESAT-6 secretion machinery protein EssA {ECO:0000250|UniProtKB:P0C052};
GN   Name=essA {ECO:0000250|UniProtKB:P0C052}; OrderedLocusNames=SAV0284;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Component of the ESAT-6 secretion system (Ess). Required for
CC       the secretion of EsxA and EsxB. {ECO:0000250|UniProtKB:P0C052}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P0C052};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EssA family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB56446.1; -; Genomic_DNA.
DR   RefSeq; WP_000928938.1; NC_002758.2.
DR   AlphaFoldDB; Q99WU2; -.
DR   TCDB; 3.A.7.17.1; the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.
DR   PaxDb; Q99WU2; -.
DR   EnsemblBacteria; BAB56446; BAB56446; SAV0284.
DR   KEGG; sav:SAV0284; -.
DR   HOGENOM; CLU_144832_0_0_9; -.
DR   OMA; LTISKWR; -.
DR   BioCyc; SAUR158878:SAV_RS01600-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR034026; EssA.
DR   InterPro; IPR018920; EssA/YueC.
DR   Pfam; PF10661; EssA; 1.
DR   TIGRFAMs; TIGR03927; T7SS_EssA_Firm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..152
FT                   /note="ESAT-6 secretion machinery protein EssA"
FT                   /id="PRO_0000019570"
FT   TOPO_DOM        1..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
SQ   SEQUENCE   152 AA;  17451 MW;  6C813CF5F1A6DA31 CRC64;
     MLMNSVIALT FLTASSNNGG LNIDVQQEEE KRINNDLNQY DTTLFNKDSK EVNDAIAKQK
     KERQQQIKND MFQNQASHST RLNETKKVLF SKSNLEKTSE SDKSPYIQNK QEKKIFPYIL
     MSVGAFLTLG FVIFSIHKGR RTKNESARKS NI