ID   ESSA_STAAR              Reviewed;         152 AA.
AC   Q6GK27;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=ESAT-6 secretion machinery protein EssA {ECO:0000250|UniProtKB:P0C052};
GN   Name=essA {ECO:0000250|UniProtKB:P0C052}; OrderedLocusNames=SAR0281;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Component of the ESAT-6 secretion system (Ess). Required for
CC       the secretion of EsxA. {ECO:0000250|UniProtKB:P0C052}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P0C052};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- MISCELLANEOUS: This strain lacks esxB and esxC. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EssA family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG39308.1; -; Genomic_DNA.
DR   RefSeq; WP_000928937.1; NC_002952.2.
DR   AlphaFoldDB; Q6GK27; -.
DR   KEGG; sar:SAR0281; -.
DR   HOGENOM; CLU_144832_0_0_9; -.
DR   OMA; LTISKWR; -.
DR   OrthoDB; 1459446at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR034026; EssA.
DR   InterPro; IPR018920; EssA/YueC.
DR   Pfam; PF10661; EssA; 1.
DR   TIGRFAMs; TIGR03927; T7SS_EssA_Firm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..152
FT                   /note="ESAT-6 secretion machinery protein EssA"
FT                   /id="PRO_0000019572"
FT   TOPO_DOM        1..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
SQ   SEQUENCE   152 AA;  17421 MW;  D79B8D5BAB5E60E1 CRC64;
     MLMNSVIALT FLTASSNNGG LNIDVQQEEE KRINNDLNQY DTTLFNKDSK AVNDAIVKQK
     KERQQQIKND MFQNQASHST RLNETKKVLF SKSNLEKTSE SDKSPYIQNK QEKKIFPYIL
     MSVGAFLTLG FVIFSIHKGR RTKNESARKS NI