ID   ESSA_STAAS              Reviewed;         152 AA.
AC   Q6GCI8;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=ESAT-6 secretion machinery protein EssA {ECO:0000250|UniProtKB:P0C052};
GN   Name=essA {ECO:0000250|UniProtKB:P0C052}; OrderedLocusNames=SAS0260;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Component of the ESAT-6 secretion system (Ess). Required for
CC       the secretion of EsxA and EsxB. {ECO:0000250|UniProtKB:P0C052}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P0C052};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EssA family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG42031.1; -; Genomic_DNA.
DR   RefSeq; WP_000928935.1; NC_002953.3.
DR   AlphaFoldDB; Q6GCI8; -.
DR   KEGG; sas:SAS0260; -.
DR   HOGENOM; CLU_144832_0_0_9; -.
DR   OMA; LTISKWR; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR034026; EssA.
DR   InterPro; IPR018920; EssA/YueC.
DR   Pfam; PF10661; EssA; 1.
DR   TIGRFAMs; TIGR03927; T7SS_EssA_Firm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..152
FT                   /note="ESAT-6 secretion machinery protein EssA"
FT                   /id="PRO_0000019573"
FT   TOPO_DOM        1..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
FT   REGION          62..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   152 AA;  17393 MW;  89956DB5A5A070F7 CRC64;
     MLMNSVIALT FLTASSNNGG LNIDVQQEEE KRINNDLNQY DTTLFNKDSK AVNDAIAKQK
     KERQQQIKND MFQNQASHST RLNETKKVLF SKSNLEKTSE SDKSPYIQNK QEKKIFPYIL
     MSVGAFLTLG FVIFSIHKGR RTKNESARKS NI