ID   ESSA_STAAW              Reviewed;         152 AA.
AC   Q8NYF4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=ESAT-6 secretion machinery protein EssA {ECO:0000250|UniProtKB:P0C052};
GN   Name=essA {ECO:0000250|UniProtKB:P0C052}; OrderedLocusNames=MW0260;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Component of the ESAT-6 secretion system (Ess). Required for
CC       the secretion of EsxA and EsxB. {ECO:0000250|UniProtKB:P0C052}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P0C052};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EssA family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB94125.1; -; Genomic_DNA.
DR   RefSeq; WP_000928935.1; NC_003923.1.
DR   AlphaFoldDB; Q8NYF4; -.
DR   EnsemblBacteria; BAB94125; BAB94125; BAB94125.
DR   KEGG; sam:MW0260; -.
DR   HOGENOM; CLU_144832_0_0_9; -.
DR   OMA; LTISKWR; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR034026; EssA.
DR   InterPro; IPR018920; EssA/YueC.
DR   Pfam; PF10661; EssA; 1.
DR   TIGRFAMs; TIGR03927; T7SS_EssA_Firm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..152
FT                   /note="ESAT-6 secretion machinery protein EssA"
FT                   /id="PRO_0000019575"
FT   TOPO_DOM        1..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..152
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:P0C052"
FT   REGION          62..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   152 AA;  17393 MW;  89956DB5A5A070F7 CRC64;
     MLMNSVIALT FLTASSNNGG LNIDVQQEEE KRINNDLNQY DTTLFNKDSK AVNDAIAKQK
     KERQQQIKND MFQNQASHST RLNETKKVLF SKSNLEKTSE SDKSPYIQNK QEKKIFPYIL
     MSVGAFLTLG FVIFSIHKGR RTKNESARKS NI