ID   ESSB_STAAC              Reviewed;         444 AA.
AC   Q5HJ87;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Type VII secretion system protein EssB {ECO:0000250|UniProtKB:Q2G185};
GN   Name=essB {ECO:0000250|UniProtKB:Q2G185}; OrderedLocusNames=SACOL0275;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Required
CC       for the secretion of EsxA and EsxB. {ECO:0000250|UniProtKB:P0C053}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2G185};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EssB family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW38829.1; -; Genomic_DNA.
DR   RefSeq; WP_000240338.1; NC_002951.2.
DR   AlphaFoldDB; Q5HJ87; -.
DR   SMR; Q5HJ87; -.
DR   EnsemblBacteria; AAW38829; AAW38829; SACOL0275.
DR   KEGG; sac:SACOL0275; -.
DR   HOGENOM; CLU_049737_0_0_9; -.
DR   OMA; FLHYGVK; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.680; -; 1.
DR   InterPro; IPR018778; T7SS_EssB.
DR   InterPro; IPR042565; T7SS_EssB_C.
DR   Pfam; PF10140; YukC; 1.
DR   TIGRFAMs; TIGR03926; T7_EssB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Membrane; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..444
FT                   /note="Type VII secretion system protein EssB"
FT                   /id="PRO_0000087062"
FT   TOPO_DOM        1..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q2G185"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..444
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q2G185"
FT   REGION          366..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          387..443
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        368..444
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  52024 MW;  FACCFE3353DE1F77 CRC64;
     MVKNHNPKNE MQDMLTPLDA EEAAKTKLRL DMREIPKSSI KPEHFHLMYL LEQHSPYFID
     AELTELRDSF QIHYDINDNH TPFDNIKSFT KNEKLRYLLN IKNLEEVNRT RYTFVLAPDE
     LFFTRDGLPI AKTRGLQNVV DPLPVSEAEF LTRYKALVIC AFNEKQSFDA LVEGNLELHK
     GTPFETKVIE AATLDLLTAF LDEQYQKQEQ DYSQNYAYVR KVGHTVFKWV AIGMTTLSVL
     LIAFLAFLYF SVMKHNERIE KGYQAFVKDD YTQVLNTYDD LDGKKLDKEA LYIYAKSYIQ
     TNKQGLEKDK KENLLNNVTP NSNKDYLLYW MELGQGHLDE AINIATYLDD NDITKLALIN
     KLNEIKNNGD LSNDKRSEET KKYNDKLQDI LDKEKQVKDE KAKSEEEKAK AKDEKLKQQE
     ENEKKQKEQA QKDKEKRQEA ERKK