ESSB_STAAM
ID ESSB_STAAM Reviewed; 444 AA.
AC Q99WU0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Type VII secretion system protein EssB {ECO:0000250|UniProtKB:Q2G185};
GN Name=essB {ECO:0000250|UniProtKB:Q2G185}; OrderedLocusNames=SAV0286;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Component of the type VII secretion system (Ess). Required
CC for the secretion of EsxA and EsxB. {ECO:0000250|UniProtKB:P0C053}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2G185};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the EssB family. {ECO:0000305}.
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DR EMBL; BA000017; BAB56448.1; -; Genomic_DNA.
DR RefSeq; WP_000240338.1; NC_002758.2.
DR AlphaFoldDB; Q99WU0; -.
DR SMR; Q99WU0; -.
DR TCDB; 3.A.7.17.1; the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.
DR PaxDb; Q99WU0; -.
DR EnsemblBacteria; BAB56448; BAB56448; SAV0286.
DR KEGG; sav:SAV0286; -.
DR HOGENOM; CLU_049737_0_0_9; -.
DR OMA; FLHYGVK; -.
DR PhylomeDB; Q99WU0; -.
DR BioCyc; SAUR158878:SAV_RS01610-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.680; -; 1.
DR InterPro; IPR018778; T7SS_EssB.
DR InterPro; IPR042565; T7SS_EssB_C.
DR Pfam; PF10140; YukC; 1.
DR TIGRFAMs; TIGR03926; T7_EssB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Membrane; Transmembrane; Transmembrane helix;
KW Virulence.
FT CHAIN 1..444
FT /note="Type VII secretion system protein EssB"
FT /id="PRO_0000087063"
FT TOPO_DOM 1..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q2G185"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..444
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q2G185"
FT REGION 366..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 387..443
FT /evidence="ECO:0000255"
FT COMPBIAS 368..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 52024 MW; FACCFE3353DE1F77 CRC64;
MVKNHNPKNE MQDMLTPLDA EEAAKTKLRL DMREIPKSSI KPEHFHLMYL LEQHSPYFID
AELTELRDSF QIHYDINDNH TPFDNIKSFT KNEKLRYLLN IKNLEEVNRT RYTFVLAPDE
LFFTRDGLPI AKTRGLQNVV DPLPVSEAEF LTRYKALVIC AFNEKQSFDA LVEGNLELHK
GTPFETKVIE AATLDLLTAF LDEQYQKQEQ DYSQNYAYVR KVGHTVFKWV AIGMTTLSVL
LIAFLAFLYF SVMKHNERIE KGYQAFVKDD YTQVLNTYDD LDGKKLDKEA LYIYAKSYIQ
TNKQGLEKDK KENLLNNVTP NSNKDYLLYW MELGQGHLDE AINIATYLDD NDITKLALIN
KLNEIKNNGD LSNDKRSEET KKYNDKLQDI LDKEKQVKDE KAKSEEEKAK AKDEKLKQQE
ENEKKQKEQA QKDKEKRQEA ERKK
