ID   ESSB_STAAR              Reviewed;         444 AA.
AC   Q6GK25;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Type VII secretion system protein EssB {ECO:0000250|UniProtKB:Q2G185};
GN   Name=essB {ECO:0000250|UniProtKB:Q2G185}; OrderedLocusNames=SAR0283;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Required
CC       for the secretion of EsxA. {ECO:0000250|UniProtKB:P0C053}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2G185};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- MISCELLANEOUS: This strain lacks esxB and esxC. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EssB family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG39310.1; -; Genomic_DNA.
DR   RefSeq; WP_000240329.1; NC_002952.2.
DR   AlphaFoldDB; Q6GK25; -.
DR   SMR; Q6GK25; -.
DR   KEGG; sar:SAR0283; -.
DR   HOGENOM; CLU_049737_0_0_9; -.
DR   OMA; FLHYGVK; -.
DR   OrthoDB; 1574313at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.680; -; 1.
DR   InterPro; IPR018778; T7SS_EssB.
DR   InterPro; IPR042565; T7SS_EssB_C.
DR   Pfam; PF10140; YukC; 1.
DR   TIGRFAMs; TIGR03926; T7_EssB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Membrane; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..444
FT                   /note="Type VII secretion system protein EssB"
FT                   /id="PRO_0000087065"
FT   TOPO_DOM        1..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q2G185"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..444
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q2G185"
FT   REGION          366..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          387..443
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        368..444
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  52039 MW;  3D3DF9721F093AFD CRC64;
     MVKNHDPKNE MQDMLTPLDA EEAAKTKLRL DMREIPKSSI KPEHFHLMYL LEQHSPYFID
     AELTELRDSF QIHYDINDNH TPFDNIKSFT KNEKLRYLLN IKNLEEVNRT RYTFVLAPDE
     LFFTRDGLPI AKTRGLQNVV DPLPVSEAEF LTRYKALVIC AFNEKQSFDA LVEGNLELHK
     GTPFETKVIE AATLDLLTAF LDEQYQKQEQ DYSQNYAYVR KVGHTVFKWV AIGMTTLSVL
     LIAFLAFLYF SVMKHNERIE KGYQAFVKED YTQVLNTYDD LDGKKLDKEA LYIYAKSYIQ
     TNKQGLEKDK KENLLNNVTP NSNKDYLLYW MELGQGHLDE AINIATYLDD NDITKLALIN
     KLNEIKNNGD LSNDKRSEET KKYNDKLQDI LDKEKQVKDE KAKSEEEKAK AKDEKLKQQE
     ENEKKQKEQA QKDKEKRQEA ERKK