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ESSC_STAAW
ID   ESSC_STAAW              Reviewed;        1479 AA.
AC   Q8NYF3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Type VII secretion system protein EssC {ECO:0000250|UniProtKB:P0C048};
GN   Name=essC {ECO:0000250|UniProtKB:P0C048}; OrderedLocusNames=MW0263;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Required
CC       for the secretion of substrates including EsxA and EsxB. However,
CC       unable to support secretion of the substrate protein EsxC.
CC       {ECO:0000250|UniProtKB:Q2G184}.
CC   -!- SUBUNIT: Homooligomer. Interacts with EsaE.
CC       {ECO:0000250|UniProtKB:Q2G184}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2G184};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EssC family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB94128.1; -; Genomic_DNA.
DR   RefSeq; WP_000549274.1; NC_003923.1.
DR   AlphaFoldDB; Q8NYF3; -.
DR   SMR; Q8NYF3; -.
DR   EnsemblBacteria; BAB94128; BAB94128; BAB94128.
DR   KEGG; sam:MW0263; -.
DR   HOGENOM; CLU_003134_2_1_9; -.
DR   OMA; WEWMKWL; -.
DR   EvolutionaryTrace; Q8NYF3; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR023839; Firmicutes_EssC_C.
DR   InterPro; IPR022206; Firmicutes_EssC_N.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   Pfam; PF01580; FtsK_SpoIIIE; 2.
DR   Pfam; PF12538; FtsK_SpoIIIE_N; 1.
DR   SUPFAM; SSF49879; SSF49879; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR03928; T7_EssCb_Firm; 1.
DR   PROSITE; PS50901; FTSK; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Repeat;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..1479
FT                   /note="Type VII secretion system protein EssC"
FT                   /id="PRO_0000098335"
FT   TOPO_DOM        1..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0C048"
FT   TRANSMEM        230..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..256
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:P0C048"
FT   TRANSMEM        257..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..1479
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0C048"
FT   DOMAIN          652..846
FT                   /note="FtsK 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   DOMAIN          997..1183
FT                   /note="FtsK 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   BINDING         672..679
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   BINDING         1014..1021
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   1479 AA;  170891 MW;  96A9A5BB1471B634 CRC64;
     MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG TWQANHTSIN
     KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGPNA YDDMVIQSLM NAIIIKDFQS
     IQESQYVRIV HDKNTDVYIN YELQEQLTNK AYIGDHIYVE GIWLEVQADG LNVLSQNTVA
     SSLIRLTQEM PHAQADDYNT YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL
     VMIALTVVIF LVRPIGIYIL MMIGMSSVTI VFGITTYFSE KKKYNKDVEK REKDYKDYLD
     NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH YKLGIANVEK
     SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND LNHGPIAYIG ARHLILEELE
     KMLIQLSIFH SYHDLEFLFV TREDEVETLK WARWLPHMTL RGQNIRGFVY NQRTRDQILT
     SIYSMIKERI QAVRERSKSN EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI
     FVEDVIESLP EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
     HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG KDDILSLNLH
     EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF LLIDYKGGGM ANLFKDLVHL
     VGTITNLDGD EAMRALTSIK AELRKRQRLF GEHDVNHINQ YHKLFKEGIA TEPMPHLFII
     SDEFAELKSE QPDFMKELVS TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ
     DRQDSNEILK TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
     MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK RPWLPPLPEN
     VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM VLQLKKAGHI ALIGSPGYGR
     TTFLHNIIFD VARHHRPDQA HMYLFDFGTN GLMPVTDIPH VADYFTVDQE DKIAKAIRIF
     NDEIDRRKKI LSQYRVTSIS EYRKLTGETI PHVFILIDNF DAVKDSPFQE VFENMMIKMT
     REGLALDMQV TLTASRANAM KTPMYINMKT RIAMFLYDKS EVSNVVGQQK FAVKDVVGRA
     LLSSDDNVSF HIGQPFKHDE TKSYNDQIND EVSAMTEFYK GETPSDIPMM PDEIKYEDYR
     ESLSLPDIVA NGALPIGLDY EGVTLQKIKL TEPAMISSEN PREIAHIAEI MMKEIDILNE
     KYAICIADSS GEFKAYRHQV ANFAEEREDI KAIHQLMIED LKQREMDGPF EKDSLYIIND
     FKTFIDCTYI PEDDVKKLIT KGPELGLNIL FVGIHKELID AYDKQIDVAR KMINQFSIGI
     RISDQQFFKF RFIQREPVIK ENEAYMVANQ AYQKIRWFK
 
 
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