ID   ESSE_STAA3              Reviewed;         224 AA.
AC   A0A0H2XFI6;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Type VII secretion system protein EsaE;
GN   OrderedLocusNames=SAUSA300_0286;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
RN   [2]
RP   FUNCTION, INTERACTION WITH ESSD, AND DISRUPTION PHENOTYPE.
RX   PubMed=27795322; DOI=10.1128/jb.00527-16;
RA   Anderson M., Ohr R.J., Aly K.A., Nocadello S., Kim H.K., Schneewind C.E.,
RA   Schneewind O., Missiakas D.;
RT   "EssE Promotes Staphylococcus aureus ESS-Dependent Protein Secretion To
RT   Modify Host Immune Responses during Infection.";
RL   J. Bacteriol. 199:0-0(2017).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Plays a
CC       role in Esx protein secretion. Plays an essential role in the
CC       processing and secretion of EssD. {ECO:0000269|PubMed:27795322}.
CC   -!- SUBUNIT: Interacts with EssD. {ECO:0000269|PubMed:27795322}.
CC   -!- DISRUPTION PHENOTYPE: Deletion affects Esx protein secretion and the
CC       production of cytokines during bloodstream infection and also impacts
CC       the ability of staphylococci to establish infectious lesions and to
CC       manipulate cellular immune responses of the host.
CC       {ECO:0000269|PubMed:27795322}.
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DR   EMBL; CP000255; ABD21119.1; -; Genomic_DNA.
DR   RefSeq; WP_000655875.1; NZ_CP027476.1.
DR   AlphaFoldDB; A0A0H2XFI6; -.
DR   EnsemblBacteria; ABD21119; ABD21119; SAUSA300_0286.
DR   KEGG; saa:SAUSA300_0286; -.
DR   HOGENOM; CLU_124476_0_0_9; -.
DR   OMA; FSYEKHE; -.
DR   Proteomes; UP000001939; Chromosome.
DR   InterPro; IPR031682; EsaE.
DR   Pfam; PF16887; DUF5081; 1.
PE   1: Evidence at protein level;
KW   Virulence.
FT   CHAIN           1..224
FT                   /note="Type VII secretion system protein EsaE"
FT                   /id="PRO_0000448087"
SQ   SEQUENCE   224 AA;  26412 MW;  5A7C121ED5F28C69 CRC64;
     MKDVKRIDYF SYEELTILGG SKLPLVNFEL FDPSNFEEAK AALIEKELVT ENDKLTDAGF
     KVATLVREYI SAIVNIRIND MYFAPFSYEK DEYILLSRFK NNGFQIRIIN KDIAWWSIVQ
     SYPLLMRQEK SNDWDFKQID DETLENLNNE SIDTIGRVLE IEIYNHQGDP QQSLYNIYEQ
     NDLLFIRYPL KDKVLNVHIG VINTFIRELF GFDTDENHIN KAEE