ID   ESSE_STAA8              Reviewed;         224 AA.
AC   Q2G181;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Type VII secretion system protein EsaE;
GN   Name=essE {ECO:0000303|PubMed:27723728}; Synonyms=esaE;
GN   OrderedLocusNames=SAOUHSC_00266;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ESSG; ESSD AND ESSC.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=27723728; DOI=10.1038/nmicrobiol.2016.183;
RA   Cao Z., Casabona M.G., Kneuper H., Chalmers J.D., Palmer T.;
RT   "The type VII secretion system of Staphylococcus aureus secretes a nuclease
RT   toxin that targets competitor bacteria.";
RL   Nat. Microbiol. 2:16183-16183(2016).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Plays a
CC       role in Esx protein secretion. Plays an essential role in the
CC       processing and secretion of EssD. {ECO:0000269|PubMed:27723728}.
CC   -!- SUBUNIT: Interacts with EssD (PubMed:27723728). Interacts with EssG
CC       (PubMed:27723728). Interacts with EssC (PubMed:27723728).
CC       {ECO:0000269|PubMed:27723728}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27723728}.
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DR   EMBL; CP000253; ABD29439.1; -; Genomic_DNA.
DR   RefSeq; WP_000655875.1; NZ_LS483365.1.
DR   RefSeq; YP_498859.1; NC_007795.1.
DR   AlphaFoldDB; Q2G181; -.
DR   EnsemblBacteria; ABD29439; ABD29439; SAOUHSC_00266.
DR   GeneID; 3919207; -.
DR   KEGG; sao:SAOUHSC_00266; -.
DR   PATRIC; fig|93061.5.peg.244; -.
DR   HOGENOM; CLU_124476_0_0_9; -.
DR   OMA; FSYEKHE; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031682; EsaE.
DR   Pfam; PF16887; DUF5081; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..224
FT                   /note="Type VII secretion system protein EsaE"
FT                   /id="PRO_0000448086"
SQ   SEQUENCE   224 AA;  26412 MW;  5A7C121ED5F28C69 CRC64;
     MKDVKRIDYF SYEELTILGG SKLPLVNFEL FDPSNFEEAK AALIEKELVT ENDKLTDAGF
     KVATLVREYI SAIVNIRIND MYFAPFSYEK DEYILLSRFK NNGFQIRIIN KDIAWWSIVQ
     SYPLLMRQEK SNDWDFKQID DETLENLNNE SIDTIGRVLE IEIYNHQGDP QQSLYNIYEQ
     NDLLFIRYPL KDKVLNVHIG VINTFIRELF GFDTDENHIN KAEE