ID   ESSG_STAA8              Reviewed;         163 AA.
AC   Q2G178;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Type VII secretion system protein EsaG;
GN   Name=essG {ECO:0000303|PubMed:27723728}; Synonyms=esaG;
GN   OrderedLocusNames=SAOUHSC_00269;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ESSD AND ESSE.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=27723728; DOI=10.1038/nmicrobiol.2016.183;
RA   Cao Z., Casabona M.G., Kneuper H., Chalmers J.D., Palmer T.;
RT   "The type VII secretion system of Staphylococcus aureus secretes a nuclease
RT   toxin that targets competitor bacteria.";
RL   Nat. Microbiol. 2:16183-16183(2016).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Acts also
CC       as part of toxin-antitoxin system. Counteracts the toxic effect of EssD
CC       via direct interaction. {ECO:0000269|PubMed:27723728}.
CC   -!- SUBUNIT: Interacts with EssD (via C-terminus) (PubMed:27723728).
CC       Interacts with EssE (PubMed:27723728). {ECO:0000269|PubMed:27723728}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27723728}.
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DR   EMBL; CP000253; ABD29442.1; -; Genomic_DNA.
DR   RefSeq; WP_000142049.1; NZ_LS483365.1.
DR   RefSeq; YP_498862.1; NC_007795.1.
DR   AlphaFoldDB; Q2G178; -.
DR   SMR; Q2G178; -.
DR   STRING; 1280.SAXN108_0277; -.
DR   EnsemblBacteria; ABD29442; ABD29442; SAOUHSC_00269.
DR   GeneID; 3919210; -.
DR   KEGG; sao:SAOUHSC_00269; -.
DR   PATRIC; fig|93061.5.peg.247; -.
DR   eggNOG; ENOG5032YNG; Bacteria.
DR   HOGENOM; CLU_107164_0_0_9; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006728; EsaG-like.
DR   InterPro; IPR036170; Prob_YezG_sf.
DR   Pfam; PF04634; DUF600; 1.
DR   SUPFAM; SSF160424; SSF160424; 1.
DR   TIGRFAMs; TIGR01741; staph_tand_hypo; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Virulence.
FT   CHAIN           1..163
FT                   /note="Type VII secretion system protein EsaG"
FT                   /id="PRO_0000448085"
SQ   SEQUENCE   163 AA;  19732 MW;  975C97C387EF173E CRC64;
     MTFEEKLSKI YNEIANEISS MIPVEWEKVY TMAYIDDGGG EVFFNYTKPG SDDLNYYTNI
     PKEYNISVQV FDDLWMDLYD LFEELRDLFK EEDLEPWTSC EFDFTREGEL KVSFDYIDWI
     NSEFGQIGRQ NYYKYRKFGI LPETEYEINK VKEIEQYIKE LEE