EST1_SCHPO
ID EST1_SCHPO Reviewed; 490 AA.
AC O74804;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Telomere elongation protein est1;
DE AltName: Full=Ever shorter telomeres protein 1;
GN Name=est1; ORFNames=SPBC2D10.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, INTERACTION WITH TRT1, AND SUBCELLULAR LOCATION.
RX PubMed=12676088; DOI=10.1016/s0960-9822(03)00169-6;
RA Beernink H.T.H., Miller K., Deshpande A., Bucher P., Cooper J.P.;
RT "Telomere maintenance in fission yeast requires an Est1 ortholog.";
RL Curr. Biol. 13:575-580(2003).
CC -!- FUNCTION: Directly involved in telomere replication. Associates with
CC telomerase and during its interaction with trt1, telomerase activity is
CC promoted. {ECO:0000269|PubMed:12676088}.
CC -!- SUBUNIT: Interacts with trt1. {ECO:0000269|PubMed:12676088}.
CC -!- INTERACTION:
CC O74804; Q10432: ccq1; NbExp=4; IntAct=EBI-1556899, EBI-15953947;
CC O74804; O13339: trt1; NbExp=3; IntAct=EBI-1556899, EBI-1556874;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12676088}.
CC Chromosome, telomere {ECO:0000305|PubMed:12676088}.
CC -!- SIMILARITY: Belongs to the EST1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21171.1; -; Genomic_DNA.
DR PIR; T40116; T40116.
DR RefSeq; NP_596232.1; NM_001022152.2.
DR AlphaFoldDB; O74804; -.
DR SMR; O74804; -.
DR BioGRID; 277020; 44.
DR DIP; DIP-38464N; -.
DR IntAct; O74804; 2.
DR STRING; 4896.SPBC2D10.13.1; -.
DR PaxDb; O74804; -.
DR EnsemblFungi; SPBC2D10.13.1; SPBC2D10.13.1:pep; SPBC2D10.13.
DR GeneID; 2540492; -.
DR KEGG; spo:SPBC2D10.13; -.
DR PomBase; SPBC2D10.13; est1.
DR VEuPathDB; FungiDB:SPBC2D10.13; -.
DR eggNOG; KOG2162; Eukaryota.
DR HOGENOM; CLU_553374_0_0_1; -.
DR OMA; YNEICTI; -.
DR Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:O74804; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IMP:PomBase.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; ISO:PomBase.
DR GO; GO:0070034; F:telomerase RNA binding; IPI:PomBase.
DR GO; GO:0032208; P:negative regulation of telomere maintenance via recombination; IGI:PomBase.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IDA:PomBase.
DR GO; GO:1905324; P:telomere-telomerase complex assembly; IMP:PomBase.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR019458; Est1_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696; PTHR15696; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..490
FT /note="Telomere elongation protein est1"
FT /id="PRO_0000087071"
SQ SEQUENCE 490 AA; 57268 MW; AAB5A05688AA3360 CRC64;
MSQQLSSNEI CEEQGKLVKA LCEAAQGGFK HDLYEKIIAI EIEVEKKLLN RLKSIQTNTF
ERPDIIWSCC HYKIIQHFRS RFREIHPRHV VEKKKTKKVF FKFLKTCAIF YQTCISELIS
KFQLDSYRPF FCKWTSSATV SSTISNDEMS SIPEASYSRN HMEALECVYN CFIYLGDMAR
YSSTCLKKRG AYDRALGFYD LAHRTLPGNG MHRNQIAVVW ASDECIVESI YWFSSALCSE
DPPKSALLNL LKQLIAFYRR CFAVHFEFVS PMMILLFIIS DCCIHSLKEI QPFKCPSIMV
KDLENSLLQS NIRNVGYEKK NLYYISSAFS NLLHCRYFNC NDRLRSFYYR FSSWLFHQTL
ACAKEVESER APTSYLTSCL PSIKVILARV LESSPAFGFI ERNELEQLSY HFRICEKFFK
ESSENKMLNL FEDYNEFGLC KSFICLFKRL NEDIIGPKLN INPPDYTTHP FSESIKRFYQ
ISKILNLLLS
