ID   EST3_ASHGO              Reviewed;         202 AA.
AC   Q75AD3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Telomere replication protein EST3;
GN   Name=EST3; OrderedLocusNames=ADL016C; ORFNames=AGOS_ADL016C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the telomerase complex involved in telomere
CC       replication. Stimulates RNA/DNA heteroduplex unwinding which favors the
CC       telomere replication by the telomerase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the telomerase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EST3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016817; AAS51905.1; -; Genomic_DNA.
DR   RefSeq; NP_984081.1; NM_209434.3.
DR   AlphaFoldDB; Q75AD3; -.
DR   SMR; Q75AD3; -.
DR   STRING; 33169.AAS51905; -.
DR   EnsemblFungi; AAS51905; AAS51905; AGOS_ADL016C.
DR   GeneID; 4620229; -.
DR   KEGG; ago:AGOS_ADL016C; -.
DR   eggNOG; ENOG502S5B8; Eukaryota.
DR   HOGENOM; CLU_1489823_0_0_1; -.
DR   InParanoid; Q75AD3; -.
DR   OMA; TVNCLFV; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IEA:EnsemblFungi.
DR   GO; GO:0033677; F:DNA/RNA helicase activity; IEA:EnsemblFungi.
DR   GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; IEA:InterPro.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:EnsemblFungi.
DR   InterPro; IPR019437; TPP1/Est3.
DR   Pfam; PF10341; TPP1; 1.
PE   3: Inferred from homology;
KW   Chromosome; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..202
FT                   /note="Telomere replication protein EST3"
FT                   /id="PRO_0000301750"
SQ   SEQUENCE   202 AA;  22392 MW;  7DDC80729B39B52B CRC64;
     MPKVVLASRA HKADSIFLRE WLVDAVVPAL ERSGACAPWA GVECFIPALP PATATLSLEP
     TVIQNPKRFL RIVRFTRVHD FAVCAVARDA GCCILVEFTP HCVSNFERRY HQRITSSTVN
     SLFVIGNTSL LFYARSDAAA AFEVPALMNG SSTLPVLRVG DCAIFDQDQV ESHRRFPLVQ
     EHPRFVQSLD MAMQGSVLSR YT