ID   EST3_CANAL              Reviewed;         210 AA.
AC   Q5A7P3; A0A1D8PIY7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Telomere replication protein EST3;
GN   Name=EST3; OrderedLocusNames=CAALFM_C300430WA;
GN   ORFNames=CaO19.12878, CaO19.5423;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the telomerase complex involved in telomere
CC       replication. Stimulates RNA/DNA heteroduplex unwinding which favors the
CC       telomere replication by the telomerase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the telomerase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EST3 family. {ECO:0000305}.
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DR   EMBL; CP017625; AOW28093.1; -; Genomic_DNA.
DR   RefSeq; XP_717795.1; XM_712702.1.
DR   AlphaFoldDB; Q5A7P3; -.
DR   STRING; 237561.Q5A7P3; -.
DR   GeneID; 3640551; -.
DR   KEGG; cal:CAALFM_C300430WA; -.
DR   CGD; CAL0000201175; EST3.
DR   VEuPathDB; FungiDB:C3_00430W_A; -.
DR   eggNOG; ENOG502RQ3Q; Eukaryota.
DR   HOGENOM; CLU_1354578_0_0_1; -.
DR   InParanoid; Q5A7P3; -.
DR   OMA; ADSTHKI; -.
DR   OrthoDB; 1516005at2759; -.
DR   PRO; PR:Q5A7P3; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IDA:CGD.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; IMP:CGD.
DR   GO; GO:0032203; P:telomere formation via telomerase; IMP:CGD.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IDA:CGD.
DR   InterPro; IPR019437; TPP1/Est3.
DR   Pfam; PF10341; TPP1; 1.
PE   3: Inferred from homology;
KW   Chromosome; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..210
FT                   /note="Telomere replication protein EST3"
FT                   /id="PRO_0000301751"
SQ   SEQUENCE   210 AA;  24359 MW;  9E0AF648313BBA9D CRC64;
     MFRSVSLSSL IPFLIIVSIA MQRPENDVPM IMQSSWLVNE VIKSINSNGQ YINALIKKDF
     QPTVLPVSFI LRILKFTATT DSKDITAVLA DSTHKIFAIF LFFPAIVDFE NKYHHRMTYN
     TRSCLIRIHK ANLKFMDKST VKKCYGRKSD GGLAIAVLEV LEFDIFFKDQ YSFINSIENR
     LKYVYDDVEY NQLCGKKKHK PEYEDLMCDI