ID   EST3_CANGA              Reviewed;         180 AA.
AC   Q6FWQ2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Telomere replication protein EST3;
GN   Name=EST3; OrderedLocusNames=CAGL0C03828g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the telomerase complex involved in telomere
CC       replication. Stimulates RNA/DNA heteroduplex unwinding which favors the
CC       telomere replication by the telomerase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the telomerase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EST3 family. {ECO:0000305}.
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DR   EMBL; CR380949; CAG58248.1; -; Genomic_DNA.
DR   RefSeq; XP_445342.1; XM_445342.1.
DR   AlphaFoldDB; Q6FWQ2; -.
DR   SMR; Q6FWQ2; -.
DR   STRING; 5478.XP_445342.1; -.
DR   EnsemblFungi; CAG58248; CAG58248; CAGL0C03828g.
DR   GeneID; 2886937; -.
DR   KEGG; cgr:CAGL0C03828g; -.
DR   CGD; CAL0127392; CAGL0C03828g.
DR   VEuPathDB; FungiDB:CAGL0C03828g; -.
DR   eggNOG; ENOG502S5B8; Eukaryota.
DR   HOGENOM; CLU_1489823_0_0_1; -.
DR   InParanoid; Q6FWQ2; -.
DR   OMA; TVNCLFV; -.
DR   Proteomes; UP000002428; Chromosome C.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IEA:EnsemblFungi.
DR   GO; GO:0033677; F:DNA/RNA helicase activity; IEA:EnsemblFungi.
DR   GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; IEA:InterPro.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:EnsemblFungi.
DR   InterPro; IPR019437; TPP1/Est3.
DR   Pfam; PF10341; TPP1; 1.
PE   3: Inferred from homology;
KW   Chromosome; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..180
FT                   /note="Telomere replication protein EST3"
FT                   /id="PRO_0000301752"
SQ   SEQUENCE   180 AA;  20965 MW;  18D6C0A773BBA090 CRC64;
     MPPFIPKSRS NAVESVYLHG WVRDMLLESK TSQNIAVIPR VDPDEASIPL LSRRIYANRR
     HFVKITKFFQ VHNYSVYASV KDSQHQILSQ FTPKCVSEFE SRNRSRITSD TVNTLFMIGD
     AKLGIMVVDE LRHYFGEKIV SLFNGLDMPY IPYLIINQAF ILDYDQVEAF KMTPFVYQYI