ID   EST3_DEBHA              Reviewed;         202 AA.
AC   Q6BQG5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Telomere replication protein EST3;
GN   Name=EST3; OrderedLocusNames=DEHA2E05434g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the telomerase complex involved in telomere
CC       replication. Stimulates RNA/DNA heteroduplex unwinding which favors the
CC       telomere replication by the telomerase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the telomerase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EST3 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG87782.2; -; Genomic_DNA.
DR   RefSeq; XP_459555.2; XM_459555.1.
DR   AlphaFoldDB; Q6BQG5; -.
DR   STRING; 4959.XP_459555.2; -.
DR   EnsemblFungi; CAG87782; CAG87782; DEHA2E05434g.
DR   GeneID; 2902956; -.
DR   KEGG; dha:DEHA2E05434g; -.
DR   VEuPathDB; FungiDB:DEHA2E05434g; -.
DR   eggNOG; ENOG502RQ3Q; Eukaryota.
DR   HOGENOM; CLU_1354578_0_0_1; -.
DR   InParanoid; Q6BQG5; -.
DR   OMA; ADSTHKI; -.
DR   OrthoDB; 1516005at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IEA:InterPro.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; IEA:InterPro.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:InterPro.
DR   InterPro; IPR019437; TPP1/Est3.
DR   Pfam; PF10341; TPP1; 1.
PE   3: Inferred from homology;
KW   Chromosome; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..202
FT                   /note="Telomere replication protein EST3"
FT                   /id="PRO_0000301753"
SQ   SEQUENCE   202 AA;  23303 MW;  62013E84A94D53ED CRC64;
     MNVNIKYPLV LHDNWLLESI TGQINKNVKY TNSLIKKDFI SPSSISKTPI LRILRFLKTT
     KSSDLTAILS DSTHTVIAIF PFDPAIINFE IRYKHRITYH TPNSLILIKQ ANLRFVNNVE
     LTTEWGITIE DEIDVAVLEV LDLEIFQRDQ IMLGVNIENN LQLIYYDKSY LNLCGKSRQR
     DSLGEKEIKE VISQSYDDVV SI