ID   EST3_KLULA              Reviewed;         184 AA.
AC   Q6CQU2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Telomere replication protein EST3;
GN   Name=EST3; OrderedLocusNames=KLLA0D14289g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the telomerase complex involved in telomere
CC       replication. Stimulates RNA/DNA heteroduplex unwinding which favors the
CC       telomere replication by the telomerase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the telomerase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EST3 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00793.1; -; Genomic_DNA.
DR   RefSeq; XP_453697.1; XM_453697.1.
DR   AlphaFoldDB; Q6CQU2; -.
DR   SMR; Q6CQU2; -.
DR   STRING; 28985.XP_453697.1; -.
DR   EnsemblFungi; CAH00793; CAH00793; KLLA0_D14289g.
DR   GeneID; 2893054; -.
DR   KEGG; kla:KLLA0_D14289g; -.
DR   eggNOG; ENOG502S5B8; Eukaryota.
DR   HOGENOM; CLU_1489823_0_0_1; -.
DR   InParanoid; Q6CQU2; -.
DR   OMA; TVNCLFV; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IEA:EnsemblFungi.
DR   GO; GO:0033677; F:DNA/RNA helicase activity; IEA:EnsemblFungi.
DR   GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; IEA:InterPro.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:EnsemblFungi.
DR   InterPro; IPR019437; TPP1/Est3.
DR   Pfam; PF10341; TPP1; 1.
PE   3: Inferred from homology;
KW   Chromosome; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..184
FT                   /note="Telomere replication protein EST3"
FT                   /id="PRO_0000301754"
SQ   SEQUENCE   184 AA;  21870 MW;  B81A962BCE851F43 CRC64;
     MPNVVLSSRL TNNDSVFLQE WIKPSVRPYY LKNEKTKFWP EQRELVTDLL EHDIIESAFQ
     TALNPAPQRF VRIVKFHRVN DYTVYATIRD STALILCYFT VDCVLDYETI NNDRITLNTL
     NTLFVIGNVT LQFWNHRECK LWFNQDFPGL RMVPVLKIEK ARMFDRDQIS SNVQFEWVYD
     TLHG