ID   ESTJ_MANSE              Reviewed;          15 AA.
AC   P19985;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Juvenile hormone esterase;
DE            Short=JH esterase;
DE            EC=3.1.1.59 {ECO:0000269|Ref.2};
DE   Flags: Fragment;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Larval plasma;
RX   PubMed=2254326; DOI=10.1016/s0021-9258(18)45801-2;
RA   Venkatesh K., Abdel-Aal Y.A.I., Armstrong F.B., Roe R.M.;
RT   "Characterization of affinity-purified juvenile hormone esterase from the
RT   plasma of the tobacco hornworm, Manduca sexta.";
RL   J. Biol. Chem. 265:21727-21732(1990).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RA   Mitsui T., Riddiford L.M., Bellamy G.;
RT   "Metabolism of juvenile hormone by the epidermis of the tobacco hornworm
RT   (Manduca sexta).";
RL   Insect Biochem. 9:637-643(1979).
CC   -!- FUNCTION: JH esterase plays a crucial role in the decrease of JH
CC       activity in lepidopteran insects, by hydrolyzing the methyl ester of
CC       JH. It is also involved in the transport of JH. {ECO:0000269|Ref.2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + juvenile hormone I = H(+) + juvenile hormone I
CC         carboxylate + methanol; Xref=Rhea:RHEA:46916, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:83641,
CC         ChEBI:CHEBI:87109; EC=3.1.1.59; Evidence={ECO:0000269|Ref.2};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + juvenile hormone III = H(+) + juvenile hormone III
CC         carboxylate + methanol; Xref=Rhea:RHEA:46912, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:27493,
CC         ChEBI:CHEBI:83274; EC=3.1.1.59; Evidence={ECO:0000269|Ref.2};
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000305}.
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DR   PIR; A36527; A36527.
DR   ESTHER; manse-jhest; Juvenile_hormone_esterase.
DR   BRENDA; 3.1.1.59; 3173.
DR   GO; GO:0004453; F:juvenile-hormone esterase activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Serine esterase.
FT   CHAIN           1..>15
FT                   /note="Juvenile hormone esterase"
FT                   /id="PRO_0000070291"
FT   NON_TER         15
SQ   SEQUENCE   15 AA;  1659 MW;  D321EA432E58B848 CRC64;
     RIPSTEEVVV RTESG