AGRG4_MOUSE
ID AGRG4_MOUSE Reviewed; 3073 AA.
AC B7ZCC9; B7ZCD0;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Adhesion G-protein coupled receptor G4;
DE AltName: Full=G-protein coupled receptor 112;
DE Flags: Precursor;
GN Name=Adgrg4; Synonyms=Gpr112;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B7ZCC9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B7ZCC9-2; Sequence=VSP_038177, VSP_038178;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
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DR EMBL; AL671998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL672263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; B7ZCC9; -.
DR STRING; 10090.ENSMUSP00000094165; -.
DR MEROPS; P02.014; -.
DR GlyGen; B7ZCC9; 5 sites.
DR iPTMnet; B7ZCC9; -.
DR PhosphoSitePlus; B7ZCC9; -.
DR PaxDb; B7ZCC9; -.
DR PeptideAtlas; B7ZCC9; -.
DR PRIDE; B7ZCC9; -.
DR ProteomicsDB; 282035; -. [B7ZCC9-1]
DR ProteomicsDB; 282036; -. [B7ZCC9-2]
DR Antibodypedia; 51733; 43 antibodies from 17 providers.
DR Ensembl; ENSMUST00000153784; ENSMUSP00000116634; ENSMUSG00000053852. [B7ZCC9-1]
DR Ensembl; ENSMUST00000154818; ENSMUSP00000119486; ENSMUSG00000053852. [B7ZCC9-2]
DR MGI; MGI:2685213; Adgrg4.
DR VEuPathDB; HostDB:ENSMUSG00000053852; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000162744; -.
DR HOGENOM; CLU_000643_0_0_1; -.
DR InParanoid; B7ZCC9; -.
DR OMA; DFYGRAD; -.
DR PhylomeDB; B7ZCC9; -.
DR ChiTaRS; Adgrg4; mouse.
DR PRO; PR:B7ZCC9; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; B7ZCC9; protein.
DR Bgee; ENSMUSG00000053852; Expressed in proximal tubule and 15 other tissues.
DR ExpressionAtlas; B7ZCC9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..3073
FT /note="Adhesion G-protein coupled receptor G4"
FT /id="PRO_0000385477"
FT TOPO_DOM 26..2691
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2692..2712
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2713..2728
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2729..2749
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2750..2755
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2756..2776
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2777..2798
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2799..2819
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2820..2842
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2843..2863
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2864..2892
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2893..2913
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2914
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2915..2935
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2936..3073
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 29..228
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT DOMAIN 2632..2683
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT REGION 253..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1945..1972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 662
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1495
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 58..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT VAR_SEQ 24
FT /note="D -> V (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_038177"
FT VAR_SEQ 25..229
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_038178"
SQ SEQUENCE 3073 AA; 334211 MW; ED17E7ED8D55EBDA CRC64;
MRKHILHQRL CGLILVSSFI FLTDSLSLKG KRLDFYGEGK AYVSLTYTMP ELSRLTACID
LISMTNSSHY WMAFIYITNN TLLGREDVDL GLAGDHQQLI LYSFGKTFYV SYHLIPFHWH
TLCLVWDGVK GRLELFRNKE RILAIMDQPH RLSPNGTLVL GHFPRNGEGQ IKTVIPRFTS
SLYYFQLWDR ILENEEFMTC FYGNVVSWED DVWLIHKISP TVDRRLRCFV SENMTIQETS
TNVSQQIDLT TSSQTTGLNP HKTSHSSTLL PEGMADSTIN STAISYANTV PSPLATVSAA
KDLKTSTTET ATFLTDTLFT STATPLPTQT VTEHSYLGKT RTSKRVEAMA TEIFHSATAT
DLIDTSVFTK NYTVSETSTT KSKSAVGKTT LFLNESTSIA PTPCPKHKST DVAILHTSKS
GQEFLVSSAA RTVSWSTLEE TSPITTDVGI VSTFPPESLL TSTASPVSST FPEIQLASTL
STTDSEMAST VHSVLPMQTI PTPRTVKPES GSTNFQDVFS PSMEDALSVS MPKETTFMAF
SSITSSPITR TQDEQIAIDA ESTHLTIIPG TKFVPTLAEA SLFPTIEGQA YTQDTPTTDE
PMLTLTSTKS PSTYNASESV LTSITIKSDY QFFTNETTWT SKSGQNLLTS MNTTTIPTFT
SNKTLTLPFQ GNATNRDHSS MTTNVSPIEA STESKVTTSS DATTASYTTA LFKPTSQWLS
HFTSVSGITS IASQPESKLT TLLLKSNSMP TVATNEFPSI PSEPVAPSVN TSTLTDIKPN
FSTEKSISET IQIETNGVSS FGDTLAPLPM SATTQRVYTT VTKETTSRHP KVKSTISTVA
EASPFSTMLE VTDESEQMVT ASVTISPFTD IEKLTTALSK ETATAEVGVS WLSTKLKESM
PESSHNGTTE SFNSTHTYTV DWTSEKSKGN SASSPNSAST QALPELPSSS TMKTMGVTFS
TNSSQRTAAS LSAGILSPQT ASTHALVTPQ LLTHTFSLPV NISAVTSPKT TMVFFDETKV
TLSQPSTLAR DFTTSMPSVG STLPTVTMTT ELVPPVSPTA STISDSMFTH RDLLHTTSEV
TTISSTTAHM AISSLRETLV SSLRPPTPVI TKAISTIPSI SSDSVSPSIH TLVCSRPSPN
NVTIVSSTYV SSTTSTSVAT PSESHFSFPY AFSSGGDVTM ASGPTGTSAG GEAMPPNTFV
NKFITSVDHE STTYFVNTPV STQSVFATSM VSSDKEQTNI SMEKTLRTTG VAEISPSKNS
FILDSQSTFP WEMTDTELSE TTEISSHQTH LPSEILPGYS DSGNLTTFST SGSTQSAQTL
SSSTIIGVRV SEGSTSLEKT ALPSQVQTVT KSLTHDKERT SALSEYPPRT VEKIMSSSPV
THQATGHLAT SIVDASRTTR ISHPVLINTT LSYLLSLKTK PEATQIASST SGSTENFPNS
FSPFTTGLLS TNFTMITPNG STTVLSIPNE PTNLPKKTSM EASTPISQMD LLALNVTAFT
SKKVSDTHTM LMTKSSRTIH IGTLKSVSIG TFGLKSEKSE MPVNNSDFST TVLYSDTSTR
LGEFFTSSSS LPPKATKTTQ ASTLNTTPVA HAGPTSQRTV FSSTFSNSSV VEVPLNYTTA
HFSSPTQRGF LSMKTIPTTS MAGISTSVIG ATSSSLSSSK NTEPISSIPK TMFSLLLSTT
QQPSQENGAP TLDILPGITV SSGGATDLIN ANSRATIPAN ELSTTPSDNF YTFLNTQDSP
TLTNSKVTPR PTESVKSTPT HLSFDTRKMN ILTELTKSGP CVTTPVLYPL WTQTSTAPPL
TSHLYSPHST KAKFPLASQM AEYPAWATGI TPSITQALLT TSRNTQRVED SPFPVFTTKV
MTPNRMEVET LHSPSGTLAT STTSQIGLVS RDVTVMPLIS TSESLPSLGI SESTSLSISS
TFPPTTLAAI LPTFEKTAMP VTPGITLSSN PSVNSRATSP TWSSSSLPSD SRASIFTPSR
LLTSSSGEMS ESTFPASDII ATYSNFTVAP LSDGSATIAT QATSTTTLDI ITANSLTSPP
IPSKDKDGSL HTSTFLESSL RTTGADSSTD MSERMSFGRT SISPSLTRHD LSIGSLTVSS
PTNTSPWSKV PVTSESHTLF PSKSTLDSVM STATTTSTAI GTSFPLMSTE MAHPSTATGF
SLVSSSFETT WMDSIFSSLF TQPSTSPTAK ESTVSFYNIK MSFSVFDEEP RVLVTTVIHD
LTKDWLNFMF QNSEFSLANL AIQIKSRKTS KEETAMYRYI LEQKKGQGMD AIFHVPYSCA
CWVIIKAKSS LESVELISSI RTKIHGNLTH GNFTQDQLTL LVKSDHVVVE KLEPGKCEAD
ETPSKYKGTY KWPLTDPTET AQERCIKNEN RNATRICSIS IQTGKCQWEK PRLKQCKLLQ
GLPDKIVDLA NITISDENAD DVAEHILNLV NESPPLDEEE TKIIVSKVAD ISNCDEISIN
LTQIILQILN TVTEKQSDSA SNLPPVSNEI LRIIERVGHK MEFAGRTANL TVAKLALAVL
RVDHKFEGMA FSIQSSEEVI APQIFLGDIP LRKALASIYL PKSLREKVPL DGLQTILFNF
FGQTSLFKAK TITSELMTYV VSASISNTSI QNLADPVIII LKHIQGDWNY DQVYCAFWDF
DTNNGLGGWN PSGCKLKESN INYTICQCNH LTHFGVLMDL SRSTVDAVNE RILVIITYTG
CGISSIFLGI AMVTYIAFHK LRKDYPSKIL INLCTALLML NLAFLVNSWL TSFQKVGLCI
TAAVALHYFL LVSLTWMGLE AVHMYFALVK VFNTYIPNYI LKFCLAGWGI PAITVAIILS
VRKDLYGTLS PTTPFCWIKD DHIFYISVVA YFCLIFLMNL SMFCTVLVQL TSVKSQSQKT
RKKMILNDLK GTISLTFLLG LTWGFAFFAW GPVRIFFLYL FAICNTLQGF LIFVFYCVMK
ESVREQWHMP LHCRWLRLEN FAGWINVRHK QKRLKKNNES KLLTPSLMST TTFKSIGSVP
SIPSEINFSN GDFDDSPDTF SFLSCKAAPT FIRRALPAEI QTNSTQKQRS FPINVSRDTH
LTPSSGLGEM FNL
