ID   ESXA_CORDI              Reviewed;          95 AA.
AC   Q6NJ54;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ESAT-6-like protein EsxA {ECO:0000303|PubMed:19854905};
GN   Name=esxA {ECO:0000303|PubMed:19854905}; OrderedLocusNames=DIP0559;
OS   Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS   gravis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=257309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX   PubMed=14602910; DOI=10.1093/nar/gkg874;
RA   Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA   Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA   De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N.,
RA   Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G.,
RA   Parkhill J.;
RT   "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT   NCTC13129.";
RL   Nucleic Acids Res. 31:6516-6523(2003).
RN   [2]
RP   SUBUNIT.
RC   STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX   PubMed=19854905; DOI=10.1128/jb.01032-09;
RA   Callahan B., Nguyen K., Collins A., Valdes K., Caplow M., Crossman D.K.,
RA   Steyn A.J., Eisele L., Derbyshire K.M.;
RT   "Conservation of structure and protein-protein interactions mediated by the
RT   secreted mycobacterial proteins EsxA, EsxB, and EspA.";
RL   J. Bacteriol. 192:326-335(2010).
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxB.
CC       {ECO:0000269|PubMed:19854905}.
CC   -!- MISCELLANEOUS: To improve expression in E.coli the proteins were cloned
CC       as a single protein in the order esxB-esxA with a cleavable thrombin
CC       tag (PubMed:19854905). {ECO:0000269|PubMed:19854905}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX248355; CAE49071.1; -; Genomic_DNA.
DR   RefSeq; WP_004566873.1; NC_002935.2.
DR   AlphaFoldDB; Q6NJ54; -.
DR   SMR; Q6NJ54; -.
DR   STRING; 257309.DIP0559; -.
DR   TCDB; 1.C.95.1.2; the pore-forming esat-6 protein (esat-6) family.
DR   EnsemblBacteria; CAE49071; CAE49071; DIP0559.
DR   GeneID; 47689938; -.
DR   KEGG; cdi:DIP0559; -.
DR   HOGENOM; CLU_151185_3_4_11; -.
DR   OMA; PLQQTWT; -.
DR   OrthoDB; 1930308at2; -.
DR   Proteomes; UP000002198; Chromosome.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..95
FT                   /note="ESAT-6-like protein EsxA"
FT                   /id="PRO_0000437936"
SQ   SEQUENCE   95 AA;  10407 MW;  714F7A9A1CAF5CD3 CRC64;
     MEKIKYGFGE IEAAASDIQS TSGRINSLLE DLKAHIRPMA AAWEGESAQA YNEAQQQWDS
     SAAELNTILS TISNTVRQGN DRMSEVNRMA AASWS