ID   ESXA_MYCLE              Reviewed;          95 AA.
AC   Q50206; O33083;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=6 kDa early secretory antigenic target homolog;
DE   AltName: Full=ESAT-6-like protein;
DE   AltName: Full=L-ESAT;
GN   Name=esxA; Synonyms=esaT6, esx, L45; OrderedLocusNames=ML0049;
GN   ORFNames=MLCB628.12c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wieles B., Notenboom T., Naafs B., Offringa R., Ottenhoff T.;
RL   Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=TN;
RX   PubMed=20085764; DOI=10.1016/j.febslet.2009.12.057;
RA   Poulsen C., Holton S., Geerlof A., Wilmanns M., Song Y.H.;
RT   "Stoichiometric protein complex formation and over-expression using the
RT   prokaryotic native operon structure.";
RL   FEBS Lett. 584:669-674(2010).
CC   -!- FUNCTION: A secreted protein that might play a role in virulence.
CC       {ECO:0000250|UniProtKB:P9WNK7}.
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxB (PubMed:20085764).
CC       {ECO:0000269|PubMed:20085764}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Probably secreted
CC       via an ESX / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WNK7}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X90946; CAA62441.1; -; Genomic_DNA.
DR   EMBL; Y14967; CAA75200.1; -; Genomic_DNA.
DR   EMBL; AL583917; CAC29557.1; -; Genomic_DNA.
DR   PIR; T10031; T10031.
DR   RefSeq; NP_301162.1; NC_002677.1.
DR   RefSeq; WP_010907487.1; NC_002677.1.
DR   AlphaFoldDB; Q50206; -.
DR   SMR; Q50206; -.
DR   IntAct; Q50206; 1.
DR   MINT; Q50206; -.
DR   STRING; 272631.ML0049; -.
DR   EnsemblBacteria; CAC29557; CAC29557; CAC29557.
DR   KEGG; mle:ML0049; -.
DR   PATRIC; fig|272631.5.peg.72; -.
DR   Leproma; ML0049; -.
DR   eggNOG; COG4842; Bacteria.
DR   HOGENOM; CLU_151185_3_4_11; -.
DR   OMA; QAVQMRW; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..95
FT                   /note="6 kDa early secretory antigenic target homolog"
FT                   /id="PRO_0000167792"
FT   CONFLICT        55
FT                   /note="R -> Q (in Ref. 1; CAA62441)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        90
FT                   /note="M -> T (in Ref. 1; CAA62441)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   95 AA;  10465 MW;  B1526F78CB2AB8A1 CRC64;
     MIQAWHFPAL QGAVNELQGS QSRIDALLEQ CQESLTKLQS SWHGSGNESY SSVQRRFNQN
     TEGINHALGD LVQAINHSAE TMQQTEAGVM SMFTG