ID   ESXA_STAA8              Reviewed;          97 AA.
AC   Q2G189;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Type VII secretion system extracellular protein A {ECO:0000250|UniProtKB:P0C046};
DE            Short=Ess extracellular protein A {ECO:0000250|UniProtKB:P0C046};
GN   Name=esxA {ECO:0000303|PubMed:18773907}; OrderedLocusNames=SAOUHSC_00257;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2] {ECO:0007744|PDB:2VRZ, ECO:0007744|PDB:2VS0}
RP   X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH ZINC, AND SUBUNIT.
RC   STRAIN=ATCC 35556 / SA113;
RX   PubMed=18773907; DOI=10.1016/j.jmb.2008.08.047;
RA   Sundaramoorthy R., Fyfe P.K., Hunter W.N.;
RT   "Structure of Staphylococcus aureus EsxA suggests a contribution to
RT   virulence by action as a transport chaperone and/or adaptor protein.";
RL   J. Mol. Biol. 383:603-614(2008).
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxA is required for EsxB synthesis as well as
CC       secretion (By similarity). Modulates host cell apoptotic pathways and
CC       mediates together with EsxB the release of S.aureus from the host cell.
CC       By acting on apoptosis, plays a role in the modulation of dendritic
CC       cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XI99, ECO:0000250|UniProtKB:P0C046}.
CC   -!- SUBUNIT: Homodimer (PubMed:18773907). When mixed with EsxB does not
CC       form heterodimers (PubMed:18773907). Crystallizes as a 4 helix bundle,
CC       the 2 subunits are anti-parallel (PubMed:18773907).
CC       {ECO:0000269|PubMed:18773907}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C046}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C046}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. sagExaA-like subfamily.
CC       {ECO:0000250|UniProtKB:Q99WU4}.
CC   -!- CAUTION: The crystal structure contains zinc ions that may be due to
CC       the crystallization medium. {ECO:0000305|PubMed:18773907}.
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DR   EMBL; CP000253; ABD29431.1; -; Genomic_DNA.
DR   RefSeq; WP_001240826.1; NZ_LS483365.1.
DR   RefSeq; YP_498851.1; NC_007795.1.
DR   PDB; 2VRZ; X-ray; 1.90 A; A/B=1-97.
DR   PDB; 2VS0; X-ray; 1.40 A; A/B=1-97.
DR   PDBsum; 2VRZ; -.
DR   PDBsum; 2VS0; -.
DR   AlphaFoldDB; Q2G189; -.
DR   SMR; Q2G189; -.
DR   STRING; 1280.SAXN108_0262; -.
DR   EnsemblBacteria; ABD29431; ABD29431; SAOUHSC_00257.
DR   GeneID; 3919199; -.
DR   GeneID; 66838585; -.
DR   KEGG; sao:SAOUHSC_00257; -.
DR   PATRIC; fig|93061.5.peg.236; -.
DR   eggNOG; COG4842; Bacteria.
DR   HOGENOM; CLU_158563_4_0_9; -.
DR   OMA; SDLKGMW; -.
DR   PRO; PR:Q2G189; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..97
FT                   /note="Type VII secretion system extracellular protein A"
FT                   /id="PRO_0000438300"
SQ   SEQUENCE   97 AA;  11036 MW;  E771B823D839B108 CRC64;
     MAMIKMSPEE IRAKSQSYGQ GSDQIRQILS DLTRAQGEIA ANWEGQAFSR FEEQFQQLSP
     KVEKFAQLLE EIKQQLNSTA DAVQEQDQQL SNNFGLQ