ID   ESXA_STAAE              Reviewed;          97 AA.
AC   P0C046; A6QDQ9;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Type VII secretion system extracellular protein A {ECO:0000305};
DE            Short=Ess extracellular protein A {ECO:0000305};
GN   Name=esxA {ECO:0000303|PubMed:15657139}; OrderedLocusNames=NWMN_0219;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION IN VIRULENCE, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Newman;
RX   PubMed=15657139; DOI=10.1073/pnas.0405620102;
RA   Burts M.L., Williams W.A., DeBord K., Missiakas D.M.;
RT   "EsxA and EsxB are secreted by an ESAT-6-like system that is required for
RT   the pathogenesis of Staphylococcus aureus infections.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:1169-1174(2005).
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxA is required for EsxB synthesis as well as
CC       secretion (PubMed:15657139). Modulates host cell apoptotic pathways and
CC       mediates together with EsxB the release of S.aureus from the host cell.
CC       By acting on apoptosis, plays a role in the modulation of dendritic
CC       cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XI99, ECO:0000269|PubMed:15657139}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15657139}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Mutant shows a significant reduction in the
CC       ability to establish kidney or liver abscesses in infected mice.
CC       {ECO:0000269|PubMed:15657139}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. sagEsxA-like subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP009351; BAF66491.1; -; Genomic_DNA.
DR   RefSeq; WP_001240826.1; NZ_CP023390.1.
DR   AlphaFoldDB; P0C046; -.
DR   SMR; P0C046; -.
DR   EnsemblBacteria; BAF66491; BAF66491; NWMN_0219.
DR   GeneID; 66838585; -.
DR   KEGG; sae:NWMN_0219; -.
DR   HOGENOM; CLU_158563_4_0_9; -.
DR   OMA; SDLKGMW; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..97
FT                   /note="Type VII secretion system extracellular protein A"
FT                   /id="PRO_0000167828"
FT   COILED          61..93
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  11036 MW;  E771B823D839B108 CRC64;
     MAMIKMSPEE IRAKSQSYGQ GSDQIRQILS DLTRAQGEIA ANWEGQAFSR FEEQFQQLSP
     KVEKFAQLLE EIKQQLNSTA DAVQEQDQQL SNNFGLQ