ID   ESXA_STAAM              Reviewed;          97 AA.
AC   Q99WU4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Type VII secretion system extracellular protein A {ECO:0000250|UniProtKB:P0C046};
DE            Short=Ess extracellular protein A {ECO:0000250|UniProtKB:P0C046};
GN   Name=esxA {ECO:0000250|UniProtKB:P0C046}; OrderedLocusNames=SAV0282;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=24586681; DOI=10.1371/journal.pone.0089313;
RA   Poulsen C., Panjikar S., Holton S.J., Wilmanns M., Song Y.H.;
RT   "WXG100 protein superfamily consists of three subfamilies and exhibits an
RT   alpha-helical C-terminal conserved residue pattern.";
RL   PLoS ONE 9:E89313-E89313(2014).
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxA is required for EsxB synthesis as well as
CC       secretion (By similarity). Modulates host cell apoptotic pathways and
CC       mediates together with EsxB the release of S.aureus from the host cell.
CC       By acting on apoptosis, plays a role in the modulation of dendritic
CC       cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XI99, ECO:0000250|UniProtKB:P0C046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C046}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C046}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. sagExaA-like subfamily.
CC       {ECO:0000305|PubMed:24586681}.
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DR   EMBL; BA000017; BAB56444.1; -; Genomic_DNA.
DR   RefSeq; WP_001240826.1; NC_002758.2.
DR   AlphaFoldDB; Q99WU4; -.
DR   SMR; Q99WU4; -.
DR   World-2DPAGE; 0002:Q99WU4; -.
DR   PaxDb; Q99WU4; -.
DR   EnsemblBacteria; BAB56444; BAB56444; SAV0282.
DR   GeneID; 66838585; -.
DR   KEGG; sav:SAV0282; -.
DR   HOGENOM; CLU_158563_4_0_9; -.
DR   OMA; SDLKGMW; -.
DR   PhylomeDB; Q99WU4; -.
DR   BioCyc; SAUR158878:SAV_RS01590-MON; -.
DR   EvolutionaryTrace; Q99WU4; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..97
FT                   /note="Type VII secretion system extracellular protein A"
FT                   /id="PRO_0000167824"
FT   COILED          61..93
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  11036 MW;  E771B823D839B108 CRC64;
     MAMIKMSPEE IRAKSQSYGQ GSDQIRQILS DLTRAQGEIA ANWEGQAFSR FEEQFQQLSP
     KVEKFAQLLE EIKQQLNSTA DAVQEQDQQL SNNFGLQ