ID   ESXA_STAAN              Reviewed;          97 AA.
AC   Q7A7S4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Type VII secretion system extracellular protein A {ECO:0000250|UniProtKB:P0C046};
DE            Short=Ess extracellular protein A {ECO:0000250|UniProtKB:P0C046};
GN   Name=esxA {ECO:0000250|UniProtKB:P0C046}; OrderedLocusNames=SA0271;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxA is required for EsxB synthesis as well as
CC       secretion (By similarity). Modulates host cell apoptotic pathways and
CC       mediates together with EsxB the release of S.aureus from the host cell.
CC       By acting on apoptosis, plays a role in the modulation of dendritic
CC       cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XI99, ECO:0000250|UniProtKB:P0C046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C046}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C046}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. sagEsxA-like subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000018; BAB41495.1; -; Genomic_DNA.
DR   PIR; D89792; D89792.
DR   RefSeq; WP_001240826.1; NC_002745.2.
DR   AlphaFoldDB; Q7A7S4; -.
DR   SMR; Q7A7S4; -.
DR   EnsemblBacteria; BAB41495; BAB41495; BAB41495.
DR   GeneID; 66838585; -.
DR   KEGG; sau:SA0271; -.
DR   HOGENOM; CLU_158563_4_0_9; -.
DR   OMA; SDLKGMW; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..97
FT                   /note="Type VII secretion system extracellular protein A"
FT                   /id="PRO_0000167825"
FT   COILED          61..93
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  11036 MW;  E771B823D839B108 CRC64;
     MAMIKMSPEE IRAKSQSYGQ GSDQIRQILS DLTRAQGEIA ANWEGQAFSR FEEQFQQLSP
     KVEKFAQLLE EIKQQLNSTA DAVQEQDQQL SNNFGLQ