ID   ESXB_MYCBO              Reviewed;         100 AA.
AC   P0A567; A0A1R3Y5R0; O69739; X2BQ42;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=ESAT-6-like protein EsxB;
DE   AltName: Full=10 kDa culture filtrate antigen CFP-10;
DE   AltName: Full=Secreted antigenic protein MTSA-10;
GN   Name=esxB; Synonyms=cfp10, lhp, mtsA10; OrderedLocusNames=BQ2027_MB3904;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: A secreted protein. Acts as a strong host T-cell antigen.
CC       Involved in translocation of bacteria from the host (human)
CC       phagolysosome to the host cytoplasm. Might serve as a chaperone to
CC       prevent uncontrolled membrane lysis by its partner EsxA.
CC       {ECO:0000250|UniProtKB:P9WNK5}.
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxA (ESAT-6).
CC       {ECO:0000250|UniProtKB:P9WNK5}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNK5}.
CC       Note=Probably secreted via the ESX-1 / type VII secretion system
CC       (T7SS). {ECO:0000250|UniProtKB:P9WNK5}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIU02536.1; -; Genomic_DNA.
DR   RefSeq; NP_857541.1; NC_002945.3.
DR   RefSeq; WP_003399940.1; NC_002945.4.
DR   AlphaFoldDB; P0A567; -.
DR   BMRB; P0A567; -.
DR   SMR; P0A567; -.
DR   EnsemblBacteria; SIU02536; SIU02536; BQ2027_MB3904.
DR   GeneID; 45427878; -.
DR   PATRIC; fig|233413.5.peg.4277; -.
DR   OMA; DISANIH; -.
DR   EvolutionaryTrace; P0A567; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   3: Inferred from homology;
KW   Chaperone; Coiled coil; Secreted; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..100
FT                   /note="ESAT-6-like protein EsxB"
FT                   /id="PRO_0000167794"
FT   REGION          81..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          49..86
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   100 AA;  10794 MW;  285F4FC96F55D194 CRC64;
     MAEMKTDAAT LAQEAGNFER ISGDLKTQID QVESTAGSLQ GQWRGAAGTA AQAAVVRFQE
     AANKQKQELD EISTNIRQAG VQYSRADEEQ QQALSSQMGF