ID   ESXB_MYCLE              Reviewed;         100 AA.
AC   O33084;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=ESAT-6-like protein EsxB;
GN   Name=esxB; OrderedLocusNames=ML0050; ORFNames=MLCB628.13c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Eiglmeier K., Garnier T., De Rossi E., Fsihi H., Cole S.T.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=TN;
RX   PubMed=20085764; DOI=10.1016/j.febslet.2009.12.057;
RA   Poulsen C., Holton S., Geerlof A., Wilmanns M., Song Y.H.;
RT   "Stoichiometric protein complex formation and over-expression using the
RT   prokaryotic native operon structure.";
RL   FEBS Lett. 584:669-674(2010).
CC   -!- FUNCTION: A secreted protein that might play a role in virulence. Might
CC       serve as a chaperone to prevent uncontrolled membrane lysis by its
CC       partner EsxA. {ECO:0000250|UniProtKB:P9WNK5}.
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxA (PubMed:20085764).
CC       {ECO:0000269|PubMed:20085764}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNK5}.
CC       Note=Probably secreted via the ESX-1 / type VII secretion system
CC       (T7SS). {ECO:0000250|UniProtKB:P9WNK5}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Y14967; CAA75210.1; -; Genomic_DNA.
DR   EMBL; AL583917; CAC29558.1; -; Genomic_DNA.
DR   PIR; T10032; T10032.
DR   RefSeq; NP_301163.1; NC_002677.1.
DR   RefSeq; WP_010907488.1; NC_002677.1.
DR   AlphaFoldDB; O33084; -.
DR   SMR; O33084; -.
DR   IntAct; O33084; 1.
DR   MINT; O33084; -.
DR   STRING; 272631.ML0050; -.
DR   EnsemblBacteria; CAC29558; CAC29558; CAC29558.
DR   KEGG; mle:ML0050; -.
DR   PATRIC; fig|272631.5.peg.73; -.
DR   Leproma; ML0050; -.
DR   eggNOG; COG4842; Bacteria.
DR   HOGENOM; CLU_178469_0_0_11; -.
DR   OMA; QAHQFER; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Reference proteome; Secreted; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..100
FT                   /note="ESAT-6-like protein EsxB"
FT                   /id="PRO_0000167795"
SQ   SEQUENCE   100 AA;  10964 MW;  460EE12F876EC383 CRC64;
     MAEMITEAAI LTQQAAQFDQ IASGLSQERN FVDSIGQSFQ NTWEGQAASA ALGALGRFDE
     AMQDQIRQLE SIVDKLNRSG GNYTKTDDEA NQLLSSKMNF