ID   ESXB_STAA8              Reviewed;         104 AA.
AC   Q2G182;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Type VII secretion system extracellular protein B {ECO:0000250|UniProtKB:P0C047};
DE            Short=Ess extracellular protein B {ECO:0000250|UniProtKB:P0C047};
GN   Name=esxB {ECO:0000303|PubMed:18773907}; OrderedLocusNames=SAOUHSC_00265;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   SUBUNIT.
RC   STRAIN=ATCC 35556 / SA113;
RX   PubMed=18773907; DOI=10.1016/j.jmb.2008.08.047;
RA   Sundaramoorthy R., Fyfe P.K., Hunter W.N.;
RT   "Structure of Staphylococcus aureus EsxA suggests a contribution to
RT   virulence by action as a transport chaperone and/or adaptor protein.";
RL   J. Mol. Biol. 383:603-614(2008).
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxB is required for EsxA synthesis as well as
CC       secretion (By similarity). Mediates together with EsxA the release of
CC       S.aureus from the host cell. Inhibits also host cytokine production and
CC       thus modulates dendritic cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XIE9, ECO:0000250|UniProtKB:P0C047}.
CC   -!- SUBUNIT: Homodimer (PubMed:18773907). When mixed with EsxA does not
CC       form heterodimers (PubMed:18773907). {ECO:0000269|PubMed:18773907}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C047}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C047}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD29438.1; -; Genomic_DNA.
DR   RefSeq; WP_000509668.1; NZ_LS483365.1.
DR   RefSeq; YP_498858.1; NC_007795.1.
DR   AlphaFoldDB; Q2G182; -.
DR   SMR; Q2G182; -.
DR   EnsemblBacteria; ABD29438; ABD29438; SAOUHSC_00265.
DR   GeneID; 3919206; -.
DR   GeneID; 66838592; -.
DR   KEGG; sao:SAOUHSC_00265; -.
DR   PATRIC; fig|93061.5.peg.243; -.
DR   HOGENOM; CLU_2248426_0_0_9; -.
DR   PRO; PR:Q2G182; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..104
FT                   /note="Type VII secretion system extracellular protein B"
FT                   /id="PRO_0000438302"
SQ   SEQUENCE   104 AA;  11510 MW;  836DC8438CCFD80B CRC64;
     MGGYKGIKAD GGKVDQAKQL AAKTAKDIEA CQKQTQQLAE YIEGSDWEGQ FANKVKDVLL
     IMAKFQEELV QPMADHQKAI DNLSQNLAKY DTLSIKQGLD RVNP